| Project/Area Number |
23790598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Kouichi 大阪大学, 医学(系)研究科(研究院), 助教 (40362694)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 悪心・嘔吐 / 発症機構 / プロスタグランジン / サブスタンスP / ロイコトリエン / プロスタグランジンE2 / アラキドン酸カスケード / 抗癌剤 / 有害反応 / 抗癌剤誘発有害反応 / 倦怠感 / 食欲不振 / 腫瘍壊死因子（TNF）-α / シスプラチン / プロスタグランジン（PG）E2 / 悪心 / シクロオキシゲナーゼ（COX）-2 / ドセタキセル |
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| Research Abstract |
Clinical reports demonstrated that nausea and vomiting occurs in many patients receiving cancer chemotherapy and surgery under general anesthesia. However, precise etiology of these symptoms are still unclear. To elucidate a possible mechanism, we tried to make an animal model of nausea and vomiting in rats and investigated the responsible neurotransmitters attributed to development of nausea and vomiting in rats. From a series of experiments, we confirmed that pica, kaolin ingestion behavior, is useful to evaluate nausea and vomiting in rats and prostaglandin E2, substance P and leukotriene may contribute to the development.
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