Neuropharmacological study on drug development targeting forbrain metabotropic glutamate 2/3 receptors
Project/Area Number |
23790599
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Osaka University |
Principal Investigator |
AGO Yukio 大阪大学, 大学院・薬学研究科, 助教 (50403027)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | うつ病 / 代謝型グルタミン酸2/3受容体 (mGlu2/3受容体) / 環境要因 / グルココルチコイド / グリア細胞 / 大脳皮質前頭前野 / 海馬 / ドパミン / 代謝型グルタミン酸2/3受容体 / 環境ストレス / グルタミン酸神経系 |
Research Abstract |
Only 30-50% of patients with depression enter remission after antidepressant treatment. Thus, discovering novel neuronal mechanisms of pathophysiology of depression as well as more effective treatments are necessary. In this study, metabotropic glutamate 2/3 receptor antagonists showed antidepressant-like effects in chronic glucocorticoid-treated mice, an animal model of conventional antidepressant-resistant depression. Chronic glucocorticoid treatment markedly increased prefrontal dopaminergic activity, and this enhanced activity was blocked by metabotropic glutamate 2/3 receptor antagonists, but not conventional antidepressants. The present findings suggest that the metabotropic glutamate 2/3 receptor is a promising target for the treatment of patients with treatment-resistant depression.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing-Induced Abnormal Behaviors in Mice2012
Author(s)
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda
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Journal Title
Journal of Pharmacological Sciences
Volume: 118
Issue: 2
Pages: 295-298
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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[Journal Article] The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.2012
Author(s)
Ago Y, Araki R, Yano K, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T
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Journal Title
Journal of Pharmacological Sciences
Volume: Vol. 118
Pages: 295-298
NAID
Related Report
Peer Reviewed
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[Journal Article] Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission2011
Author(s)
Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T
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Journal Title
Psychopharmacology (Berl)
Volume: 217(3)
Issue: 3
Pages: 443-52
DOI
Related Report
Peer Reviewed
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[Journal Article] Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission.2011
Author(s)
Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T
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Journal Title
Psychopharmacology (Berl)
Volume: Vol. 217
Pages: 443-452
Related Report
Peer Reviewed
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