Development of in vivo evaluation method for drug transporter-mediated drug interactions using nadolol
| Project/Area Number |
23790605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
MISAKA Shingen 福島県立医科大学, 医学部, 助教 (10583635)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 薬物トランスポーター / ナドロール / 薬食相互作用 / 薬物間相互作用 / 臨床試験 / 緑茶 / 薬物相互作用 / 活性指標薬 / 薬物動態 / 国際情報交換 |
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| Research Abstract |
We investigated 1) whether nadolol is a substrate of drug transporters and 2) whether nadolol could be a novel in vivo probe drug for the evaluation of drug transporter-mediated drug interactions. In vitro experiments revealed that nadolol is a substrate of some drug transporters such as organic anion transporting polypeptide 1A2. In addition, we demonstrated for the first time that green tea ingestion markedly reduced plasma concentrations of nadolol as well as its blood pressure lowering effect in healthy volunteers. These findings indicate 1) the usefulness of nadolol as an in vivo probe drug for drug transporters, and 2) possible food-drug interactions caused by green tea.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Response to effect of green tea with exceptionally high catechin content on nadolol plasma concentration2014
Author(s)
Shingen Misaka, Junichi Yatabe, Fabian Müller, Kozue Takano, Hartmut Glaeser, Midori S. Yatabe, Satomi Onoue, José P. Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F. Fromm, Junko Kimura
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Journal Title
Clinical Pharmacology and Therapeutics
Volume: 95 (6)
Pages: 589-589
Related Report
Peer Reviewed
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[Journal Article] Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects2014
Author(s)
Shingen Misaka, Junichi Yatabe, Fabian Müller, Kozue Takano, Keisuke Kawabe, Hartmut Glaeser, Midori S. Yatabe, Satomi Onoue, José P. Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F. Fromm, Junko Kimura
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Journal Title
Clinical Pharmacology and Therapeutics
Volume: 95 (4)
Pages: 432-438
Related Report
Peer Reviewed
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[Journal Article] Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects2014
Author(s)
Shingen Misaka, Junichi Yatabe, Fabian Mueller, Kozue Takano, Keisuke Kawabe, Hartmut Glaeser, Midori S. Yatabe, Satomi Onoue, Jose P. Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F. Fromm, Junko Kimura
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Journal Title
Clinical Pharmacology and Therapeutics
Volume: 95
Issue: 4
Pages: 432-438
DOI
Related Report
Peer Reviewed
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[Presentation] Effects of chronic consumption of green tea on the pharmacokinetics and pharmacodynamics of nadolol in healthy volunteers2012
Author(s)
Shingen Misaka, Nozomu Miyazaki, Junichi Yatabe, Keisuke Kawabe, Kozue Takano, Tomoyuki Ono, Satomi Onoue, Tetsuhito Fukushima, Hiroshi Watanabe, Shizuo Yamada, Junko Kimura
Organizer
113th American Society for Clinical Pharmacology and Therapeutics Annual Meeting
Place of Presentation
National Harbor, Maryland
Related Report
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