| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We investigated 1) whether nadolol is a substrate of drug transporters and 2) whether nadolol could be a novel in vivo probe drug for the evaluation of drug transporter-mediated drug interactions. In vitro experiments revealed that nadolol is a substrate of some drug transporters such as organic anion transporting polypeptide 1A2. In addition, we demonstrated for the first time that green tea ingestion markedly reduced plasma concentrations of nadolol as well as its blood pressure lowering effect in healthy volunteers. These findings indicate 1) the usefulness of nadolol as an in vivo probe drug for drug transporters, and 2) possible food-drug interactions caused by green tea.
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