Analysis of the mechanisms of allopurinol-induced severe cutaneous adverse reactions
| Project/Area Number |
23790611
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
SUGIYAMA Emiko 国立医薬品食品衛生研究所, 医薬安全科学部, 研究助手 (40574695)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 医薬品副作用 / 反応性代謝物 / アロプリノール / 重症薬疹 / 副作用 |
|---|
| Research Abstract |
To investigate whether allopurinol or phenytoin generate drug-protein adduct, each drugs were incubated with various human liver tissues. As a result, it is suggested that cytochrome P450 activities and the concentration of glutathione in cells are of importance for generation of drug-protein adduct formation with phenytoin. In addition, although it have not been reported that P450 activities are involved in the allopurinol metabolism, the result of this study suggested that P450 activities played a role in generation of the drug-protein adduct.
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Report
(3 results)
Research Products
(1 results)
