| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
To investigate whether allopurinol or phenytoin generate drug-protein adduct, each drugs were incubated with various human liver tissues. As a result, it is suggested that cytochrome P450 activities and the concentration of glutathione in cells are of importance for generation of drug-protein adduct formation with phenytoin. In addition, although it have not been reported that P450 activities are involved in the allopurinol metabolism, the result of this study suggested that P450 activities played a role in generation of the drug-protein adduct.
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