| Project/Area Number |
23790616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SAITO Ryoichi 東京医科歯科大学, 大学院・保健衛生学研究科, 准教授 (00581969)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | モラクセラ・カタラーリス / 外膜蛋白質 / 薬剤耐性 / Moraxella catarrhalis / OMPCD / 増殖 / 細胞形態 / 細胞付着性 / 膜疎水性 / 病原因子 |
|---|
| Research Abstract |
To contribute to the prevention and treatment of Moraxella catarrhalis infection, the present study was undertaken to investigate the function of M. catarrhalis OMPCD. Expression of OMPCD was found to be stable under various stress environments. Furthermore, our findings confirmed that OMPCD plays a role in bacterial physiology, including aspects such as bacterial growth and stabilization of bacterial cell morphology; penicillin resistance; and pathogenesis, such as adherence to human epithelial cells and serum resistance.
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