Development of rapid generation of antibodies with high affinity for improvement of detection limi
| Project/Area Number |
23790617
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
OZAWA Tatsuhiko 富山大学, 大学院・医学薬学研究部(医学), 助教 (10432105)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 臨床検査医学 / 高親和性抗体 / ウサギモノクローナル抗体 / ISAAC / 抗体医薬 |
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| Research Abstract |
Antigen-specific rabbit monoclonal antibodies （RaMoAbs) are useful due to their high specificity and high affinity, and the establishment of a comprehensive and rapid RaMoAb generation system has been highly anticipated. Here, we present a novel system for rapid RaMoAb generation and produce antigen-specific RaMoAbs with high affinity within a time period of only 7 days. We have used this system to efficiently generate RaMoAbs that are specific to a phosphorylated signal-transducing molecule. Our system provides a new method for the comprehensive and rapid production of RaMoAbs, which may contribute to laboratory research and clinical applications.交付決定額
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Report
(3 results)
Research Products
(43 results)
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[Presentation] Cloning of human antigen-specific TCRs can confer the candidates for cancer gene therapy2012
Author(s)
Kobayashi E, Mizukoshi E, Kishi H, Hamana H, Nagai T, Ozawa T, Nakagawa H, Jin A, Kaneko S, Muraguchi A
Organizer
SITC 27th Annual Meeting
Place of Presentation
North Bethesda, MD, USA
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