Development ofrapid cancer diagnosis by the novel electrospray ionization-mass spectrometry
Project/Area Number |
23790619
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
|
Research Institution | University of Yamanashi |
Principal Investigator |
YOSHIMURA Kentaro 山梨大学, 大学院・医学工学総合研究部, 助教 (70516921)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 質量分析 / 学習機械 / がん診断 / 大気圧 / エレクトロスプレー / ベイズ統計学 |
Research Abstract |
Probe electrospray ionization (PESI) is a biocompatible ambient ionization technique. We determined the conditions of measurements for lipids in human tissues. More than 3,000 spectra datasets were obtained from specimens of human renal cell carcinoma and hepatocellular carcinoma. These data were used as a training dataset, which serves as a reference for the dPLRM. We input randomly selected test datasets to the dPLRM to get probabilistic result of cancer diagnosis. We achieved over 90% coincidence of diagnosis with those judged by the conventional histopathology.
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Report
(3 results)
Research Products
(42 results)