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Novel validation system for biologicaI drug efficacy in rheumatoid arthritis

Research Project

Project/Area Number 23790621
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionKyoto University

Principal Investigator

YAMAMOTO Yasuko  京都大学, 医学(系)研究科(研究院), 助教 (00331869)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsrheumatoid arthritis / indoleamine 2,3-dioxygenase 1 / 関節リウマチ / 薬効予測システム / IDO1 / 自己免疫性疾患 / 薬効予測
Research Abstract

Recently, biological agents have been used for treatment of rheumatoid arthritis (RA), but there is a subset of patients who do not response to drug therapy. This study aimed to establish the novel validation system for the efficacy of biological agents in patients with RA.
An increased tryptophan catabolism via the kynurenine pathway throughout RA patients has been observed. So, we evaluated the biological agents efficiency based on the L-tryptophan catabolism in vitro blood culture. Our results showed that kynurenine levels correlated with CDAI score and SDAI score after biological agents treatment. These methods will be useful for the selection of biological drugs for RA patients.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases : potential role in macrophage-mediated inflammatory diseases2013

    • Author(s)
      Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yalnamoto Y, Saito K
    • Journal Title

      Mediators Inflamm

      Volume: (In Press)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases : potential role in macrophage-mediated inflammatory diseases2013

    • Author(s)
      Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yamamoto Y, Saito K
    • Journal Title

      Mediators Inflamm

      Volume: 2013 Pages: 391984-391984

    • DOI

      10.1155/2013/391984

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] キャピラリー電気泳動の波形パターンを用いた検査システムに関する研究2012

    • Author(s)
      坪井彩
    • Organizer
      第59回日本臨床検査医学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 関節リウマチ患者における生物学的製剤の有効性の予測方法

    • Inventor(s)
      斉藤 邦明、山本 康子、坪井 彩
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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