Proteomic-based identification of renal tubular markers related to the new mechanism of urinary albumin excretion.
| Project/Area Number |
23790627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Bunkyo Gakuin University |
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Principal Investigator |
NAKAYAMA Aki 文京学院大学, 保健医療技術学部 臨床検査学科, 助手 (00599425)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 尿中アルブミン / Tamm-Horsfall protein / エキソソーム / 尿中Tamm-Horsfall protein / 尿中エキソソーム / 尿中タンパク質 |
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| Research Abstract |
The urinary albumin peptides metabolized in the renal tubular cells and excreted into urine, and which is considered as an in-direct tubular marker were identified by proteome analysis. The quantitative analysis of urinary Tamm-Horsfall protein showed that the significant decrease level in the patients with renal dysfunction. The proteome analysis of urinary exosomes enabled the identification of variety types of protein derived from renal epithelial cells. These results provide the basic information to predict the tubular dysfunction in renal disease condition.
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Report
(3 results)
Research Products
(32 results)
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[Presentation] Cellulose acetate membrane electrophoresis coupled with sensitive colloidal silver staining for urinary protein analysis: A rapid and simple approach for predicting the renal injury2011
Author(s)
Ryo Kubota, Aki Nakayama (equal contribution), Junya Odake, Minoru Sakatsume, Takeshi Kasama, Ichiei Narita, Nobue Sakai, Kiyoko Kanamori, Kiyoko Shiba
Organizer
Annual meeting 2011, American Association for Clinical Chemistry
Place of Presentation
Atranta, GA, USA
Related Report
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