Development of the quantitative analysis of autoantibodies toADAMTS13 in patients with thrombotic thrombocytopenic purpura.

• Project/Area Number: 23790629
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Keio University
• Principal Investigator: IGARI Atsuko 慶應義塾大学, 医学部, 研究員 (60594893)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ADAMTS13 / 自己抗体 / 高感度定量測定

Research Abstract

The production of autoantibodies to ADAMTS13 is considered as a pivotal pathophysiology of acquired thrombotic thrombocytopenic purpura (TTP). The aim of this study was to perform a radioimmunoprecipitation assay to quantify the autoantibodies to ADAMTS13

Research Products

• [Presentation] 後天性TTPにおける抗ADAMTS13自己抗体の定量的測定 (2013)
  • Author(s): 猪狩敦子
  • Organizer: 第35回日本血栓止血学会学術集会
  • Place of Presentation: 山形・山形国際ホテル
• [Presentation] ADAMTS13 機能ドメインを特異的に認識する自己抗体の定量測定系に関する検討 (2012)
  • Author(s): 猪狩 敦子、森木隆典、山口雄亮、中川央充、和田英夫、松本雅則、藤村吉博、副島見事、村田満
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-08
• [Presentation] ADAMTS13機能ドメインを特異的に認識する自己抗体の定量測定系に関する検討 (2012)
  • Author(s): 猪狩敦子
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: 東京・ハイアットリージェンシー東京
• [Presentation] Quantitative analysis of the domain-specific autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura (2011)
  • Author(s): Igari A, Moriki T, Yamaguchi Y, Nakagawa T, Wada H, Matsumoto M, Fujimura Y, Soejima K, Murata M
  • Organizer: The 53th Annual Meeting and Exposition, American Society of Hematology
  • Place of Presentation: SanDiego,CA
  • Year and Date: 2011-12-10
• [Presentation] Quantitative analysis of the domain-specific autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura (2011)
  • Author(s): 猪狩敦子
  • Organizer: 53th Annual Meeting and Exposition, The American Society of Hematology (第53回アメリカ血液学会)
  • Place of Presentation: アメリカ、サンディエゴ、サンディエゴコンベンションセンター