Regulation of NK cell activation by glycan
| Project/Area Number |
23790631
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Toho University |
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Principal Investigator |
HIGAI Koji 東邦大学, 薬学部, 准教授 (70297711)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | NK細胞 / 細胞傷害 / 糖鎖リガンド / シアル酸 / レクチン受容体 / 多糖類 / KLRs / NCRs |
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| Research Abstract |
In this study, we tried to clarify the regulation of activation of NK cells by polysaccharides. The reported glycanligands of NKRs and NCRs affected the cytotoxicity by NK cells and up-regulation of CD3zeta phosphorylation. These results suggested that the specific glycan of target cells affected the NK activation via NCR1 or NCR3 molecules
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Report
(3 results)
Research Products
(24 results)
