The analysis of high coagulant microparticles on venous thromboembolism complicated with ovarian cancer

• Project/Area Number: 23790633
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター (2012); Kanagawa Cancer Center Research Institute (2011)
• Principal Investigator: ITO Shin 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター, 臨床研究所, 特別研究員 (00460139)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腫瘍検査学 / マイクロパーティクル / 卵巣癌 / 血栓塞栓症

Research Abstract

In this study, we found that the ovarian cancer cells secrete a larger number of microparticles (MPs) than any other types of cancer. The MPs with high coagulant activities merged to fibroblast cells and were maintained for a long time. We suggest that TF bearing MPs may play major roles in TF-VIIa activity of ovarian cancer tissues rather than activation of peripheral thrombosis. These suggest that high coagulant MPs from ovarian cancer cells result venous thrombosis on ovarian cancer patients

Research Products

• [Journal Article] HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells (2012)
  • Author(s): Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y
  • Journal Title: Nucleic Acid Research Volume: 40(12) Issue: 12 Pages: 5389-5401
  • DOI: 10.1093/nar/gks201
  • Peer Reviewed
• [Presentation] Aberrant expression of TFPI-1 associated with low procoagulant activity of liver cancer cells (2013)
  • Author(s): Shin Ito, Shiro Koizume, Yuji Sakuma, Roppei Yamada, Wolfram Ruf, Yasuo Takano, Yohei Miyagi
  • Organizer: AACR Annual Meeting
  • Place of Presentation: Washington, DC
• [Presentation] 宮城洋平肝細胞癌で発現する異所性TFPI1 による癌細胞での接着阻害 (2012)
  • Author(s): 伊藤慎、小井詰史朗、高野康雄、宮城洋平
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
• [Presentation] Inhibition of hepatocellular carcinoma cell adhesion by ectopic synthesis of TFPI1 (2012)
  • Author(s): 伊藤 慎
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 肝細胞癌で見られるTF 及びTFPI1 の特異的な発現 (2011)
  • Author(s): 伊藤慎、小井詰史朗、中村圭靖、宮城洋平
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] 肝細胞癌で見られるTF及びTFPI1の特異的な発現 (2011)
  • Author(s): 伊藤慎、小井詰史朗、中村圭靖、高野康雄、宮城洋平
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋国際会議場