The analysis of high coagulant microparticles on venous thromboembolism complicated with ovarian cancer
| Project/Area Number |
23790633
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター (2012)
Kanagawa Cancer Center Research Institute (2011) |
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Principal Investigator |
ITO Shin 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター, 臨床研究所, 特別研究員 (00460139)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍検査学 / マイクロパーティクル / 卵巣癌 / 血栓塞栓症 |
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| Research Abstract |
In this study, we found that the ovarian cancer cells secrete a larger number of microparticles (MPs) than any other types of cancer. The MPs with high coagulant activities merged to fibroblast cells and were maintained for a long time. We suggest that TF bearing MPs may play major roles in TF-VIIa activity of ovarian cancer tissues rather than activation of peripheral thrombosis. These suggest that high coagulant MPs from ovarian cancer cells result venous thrombosis on ovarian cancer patients
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Report
(3 results)
Research Products
(6 results)
