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Analysis of gene expression regulation of intelectin-1 in malignant pleural mesothelioma

Research Project

Project/Area Number 23790634
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionKanagawa Cancer Center Research Institute

Principal Investigator

YAMASHITA Makiko  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 客員研究員 (60397776)

Research Collaborator TSUJI Shoutaro  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん治療学部, 主任研究員 (30285192)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords中皮腫 / インテレクチン
Research Abstract

In this study, we found that intelectin-1 was expressed in malignant pleural mesothelioma (MPM) or intestinal metaplasia in stomach, but not in normal pleura and normal stomach. However, expression of other lesion markers was not similar. Therefore, intelectin-1 expression in MPM and intestinal metaplasia may be regulated by different gene regulatory mechanisms each other. The promoter and enhancer of intelectin-1 in MPM located on a region from -56 to +6 nucleotides including a TATA box element and from +263 to +293 nucleotides, respectively, for the transcription start site. Database analysis of the enhancer region suggested that Oct and Sox transcriptional factors might function as transcriptional factors of intelectin-1 in MPM.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Hishot display—a new combinatorial display for obtaining target-recognizing peptides2013

    • Author(s)
      Shoutaro Tsuji, Makiko Yamashita, Taihei Kageyama, Takashi Ohtsu, Katsuo Suzuki, Shintaro Kato, Joe Akitomi, Makio Furuichi, and Iwao Waga
    • Journal Title

      PLoS ONE

      Volume: 8(12) Issue: 12 Pages: e83108-e83108

    • DOI

      10.1371/journal.pone.0083108

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specific expression of human intelectin-1 in malignant pleural mesothelioma and gastrointestinal goblet cells2012

    • Author(s)
      Kota Washimi, Tomoyuki Yokose, Makiko Yamashita, Taihei Kageyama, Katsuo Suzuki, Mitsuyo Yoshihara, Yohei Miyagi, Hiroyuki Hayashi, and Shoutaro Tsuji
    • Journal Title

      PLoS ONE

      Volume: 7(7) Issue: 7 Pages: e39889-e39889

    • DOI

      10.1371/journal.pone.0039889

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Hishot display - a new combinatorial display for obtaining artificial antibody2013

    • Author(s)
      Shoutaro Tsuji, Makiko Yamashita, Taihei Kageyama, Takashi Ohtsu, Katsuo Suzuki, Shintaro Kato, Joe Akitomi, Makio Furuichi, Iwao Waga
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 上皮型中皮腫におけるインテレクチン-1の発現と診断マーカーとしての評価2013

    • Author(s)
      辻祥太郎、影山泰平、鷲見公太、山下真紀子、横瀬智之、諸星隆夫、津浦幸夫
    • Organizer
      第4回Japan Mesothelioma Interest Group研究会
    • Place of Presentation
      京都私学会館(京都)
    • Year and Date
      2013-08-31
    • Related Report
      2013 Final Research Report
  • [Presentation] インテレクチン-1は上皮型悪性胸膜中皮腫の優れた診断マーカーである2012

    • Author(s)
      Shoutaro Tsuji, Kota Washimi, Makiko Yamashita, Taihei Kageyama, Katsuo Suzuki, Mitsuyo Yoshihara, Yohei Miyagi
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性胸膜中皮腫と腸上皮化生におけるマーカー蛋白質の発現の比較2012

    • Author(s)
      Makiko Yamashita, Kota Washimi, Taihei Kageyama, Katsuo Suzuki, Mitsuyo Yoshihara, Tomoyuki Yokose, Yohei Miyagi, Shoutaro Tsuji
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対するモノクローナル抗体の作製2012

    • Author(s)
      Taihei Kageyama, Makiko Yamashita, Katsuo Suzuki, Mitsuyo Yoshihara, Kota Washimi, Tomoyuki Yokose, Yohei Miyagi, Shoutaro Tsuji
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Hishot display - a new combinatorial display for obtaining artificial antibody.

    • Author(s)
      Shoutaro Tsuji
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上皮型中皮腫におけるインテレクチン-1の発現と診断マーカーとしての評価

    • Author(s)
      辻祥太郎
    • Organizer
      第4回Japan Mesothelioma Interest Group研究会
    • Place of Presentation
      京都私学会館(京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫と腸上皮化生におけるマーカー蛋白質の発現の比較

    • Author(s)
      山下真紀子
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市ロイトン札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] インテレクチン-1は上皮型悪性胸膜中皮腫の優れたマーカーである

    • Author(s)
      辻祥太郎
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市ロイトン札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 悪性胸膜中皮腫に対するモノクローナル抗体の作製

    • Author(s)
      影山泰平
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市ロイトン札幌
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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