Analysis of gene expression regulation of intelectin-1 in malignant pleural mesothelioma
| Project/Area Number |
23790634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanagawa Cancer Center Research Institute |
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Principal Investigator |
YAMASHITA Makiko 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 客員研究員 (60397776)
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| Research Collaborator |
TSUJI Shoutaro 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん治療学部, 主任研究員 (30285192)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 中皮腫 / インテレクチン |
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| Research Abstract |
In this study, we found that intelectin-1 was expressed in malignant pleural mesothelioma (MPM) or intestinal metaplasia in stomach, but not in normal pleura and normal stomach. However, expression of other lesion markers was not similar. Therefore, intelectin-1 expression in MPM and intestinal metaplasia may be regulated by different gene regulatory mechanisms each other. The promoter and enhancer of intelectin-1 in MPM located on a region from -56 to +6 nucleotides including a TATA box element and from +263 to +293 nucleotides, respectively, for the transcription start site. Database analysis of the enhancer region suggested that Oct and Sox transcriptional factors might function as transcriptional factors of intelectin-1 in MPM.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] インテレクチン-1は上皮型悪性胸膜中皮腫の優れた診断マーカーである2012
Author(s)
Shoutaro Tsuji, Kota Washimi, Makiko Yamashita, Taihei Kageyama, Katsuo Suzuki, Mitsuyo Yoshihara, Yohei Miyagi
Organizer
第71回日本癌学会学術総会
Place of Presentation
ロイトン札幌(北海道)
Year and Date
2012-09-21
Related Report
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[Presentation] 悪性胸膜中皮腫と腸上皮化生におけるマーカー蛋白質の発現の比較2012
Author(s)
Makiko Yamashita, Kota Washimi, Taihei Kageyama, Katsuo Suzuki, Mitsuyo Yoshihara, Tomoyuki Yokose, Yohei Miyagi, Shoutaro Tsuji
Organizer
第71回日本癌学会学術総会
Place of Presentation
ロイトン札幌(北海道)
Year and Date
2012-09-21
Related Report
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[Presentation] 悪性胸膜中皮腫に対するモノクローナル抗体の作製2012
Author(s)
Taihei Kageyama, Makiko Yamashita, Katsuo Suzuki, Mitsuyo Yoshihara, Kota Washimi, Tomoyuki Yokose, Yohei Miyagi, Shoutaro Tsuji
Organizer
第71回日本癌学会学術総会
Place of Presentation
ロイトン札幌(北海道)
Year and Date
2012-09-21
Related Report
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