Pruritus caused by endothelin from keratinocytes and new treatement targeting its endothelin
| Project/Area Number |
23790637
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Hirosaki University |
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Principal Investigator |
JIN Kayo 弘前大学, 医学部附属病院, 医員 (60422060)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | そう痒 / 表皮 / エンドセリン / レセプター / シグナル |
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| Research Abstract |
Endothelin is produced by endothelial cells and potent vasoconstrictor. We have recently concentrated on endothelin study and demonstrated that endothelin synthesized by keratinocytes binds to ETR of melanocytes and induce pigmentation by action with MITF. Skin disease with epidermal changes such as eczema, atopic dermatitis, pururigo, erythrodermia, solar dermatitis has no or little response against anti-histamines. The purpose of this study is involvement of endothelin in those itchy skin diseases and establish new treatments to those diseases. The results of this study suggests that endothelin may play some role in itching sensation of the skin, but are not sufficient. Therefore, further study need for strong clarification.
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Report
(3 results)
Research Products
(7 results)
