| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To clarify the distribution of hip pain, 443 hips with osteoarthritis were studied. Distribution of pain originating in the hip was 89 % to the groin, 38 % to the buttock, 33 % to the anterior thigh, 29 % to the knee, 27 % to the greater trochanter, 17 % to the low back, and 8 % to the lower leg. When the anterior thigh, knee, lower leg, and low back were combined as the referral region, 55 % showed referred pain.
To clarify the sensory innervation and inflammatory cytokines in hypertrophic synovia associated with pain transmission, a piece of the synovium was extracted in 50 patients with osteoarthritis of the hip as an inflammatory synovium and in 12 patients with femoral neck fracture as a normal synovium. In the inflammatory synovium, TuJ-1 was positive in46%. Of those positive for TuJ-1, 78% were also positive for CGRP. NF-κB was positive in68%. Of those positive for NF-kB, 76% were also positive for TNF-α. In normal synovia, all four substances were negative.
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