Morphological analysis of limbic modulation of descending pain inhibitory system
| Project/Area Number |
23790643
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
OKA Tatsuro 島根大学, 医学部, 助教 (20508923)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 下行性疼痛抑制系 / 中心灰白質 / 辺縁系 / 視床下部 / 扁桃体 / 大縫線核 / 神経回路 / ラット |
|---|
| Research Abstract |
To understand how limbic structures influence descending antinociceptive system, we examined whether hypothalamic and amygdaloid terminals make synaptic contact with rostral ventromedial medulla (RVM)-projecting neurons in the periaqueductal gray (PAG). As a result, prominent overlapping distribution of the ventromedial hypothalamic axons and RVM-projecting neurons was observed in the lateral/dorsomedial part of the PAG. Furthermore, electron microscopic observation revealed that ventromedial hypothalamic terminals made asymmetrical synaptic contactswith RVM-projecting PAG neurons. We further demonstrated that most of the RVM-projecting PAG neurons are positive for vesicular glutamate transporter 2 mRNA, suggesting that these neurons are glutamatergic.
|
Report
(3 results)
Research Products
(12 results)
