Morphological analysis of limbic modulation of descending pain inhibitory system

• Project/Area Number: 23790643
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Shimane University
• Principal Investigator: OKA Tatsuro 島根大学, 医学部, 助教 (20508923)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 下行性疼痛抑制系 / 中心灰白質 / 辺縁系 / 視床下部 / 扁桃体 / 大縫線核 / 神経回路 / ラット

Research Abstract

To understand how limbic structures influence descending antinociceptive system, we examined whether hypothalamic and amygdaloid terminals make synaptic contact with rostral ventromedial medulla (RVM)-projecting neurons in the periaqueductal gray (PAG). As a result, prominent overlapping distribution of the ventromedial hypothalamic axons and RVM-projecting neurons was observed in the lateral/dorsomedial part of the PAG. Furthermore, electron microscopic observation revealed that ventromedial hypothalamic terminals made asymmetrical synaptic contactswith RVM-projecting PAG neurons. We further demonstrated that most of the RVM-projecting PAG neurons are positive for vesicular glutamate transporter 2 mRNA, suggesting that these neurons are glutamatergic.

Research Products

• [Journal Article] Glutamatergic neurons in the lateral periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat (2012)
  • Author(s): Tatsuro Oka
  • Journal Title: Neuroscience Research Volume: 74 Issue: 2 Pages: 106-115
  • DOI: 10.1016/j.neures.2012.08.001
  • Peer Reviewed
• [Journal Article] Projections from the anterior basomedial and anterior cortical amygdaloid nuclei to melanin-concentrating hormone-containing neurons in the lateral hypothalamus of the rat (2012)
  • Author(s): Niu JG, Yokota S, Tsumori T, Oka T,Yasui Y
  • Journal Title: Brain Research Volume: 1479 Pages: 31-43
  • DOI: 10.1016/j.brainres.2012.08.011
  • Peer Reviewed
• [Journal Article] Glutamatergic Kolliker-Fuse nucleus neurons innervate hypoglossal motoneurons whose axons form the medial (protruder)branch of the hypoglossal nerve in therat (2011)
  • Author(s): Yokota S, Niu JG, Tsumori T, Oka T,Yasui Y
  • Journal Title: Brain Research Volume: 1404 Pages: 10-20
  • DOI: 10.1016/j.brainres.2011.06.025
  • Peer Reviewed
• [Journal Article] Glutamatergic Kolliker-Fuse nucleus neurons innervate hypoglossal motoneurons whose axons form the medial (protruder) branch of the hypoglossal nerve in the rat. (2011)
  • Author(s): Shigefumi Yokota
  • Journal Title: Brain Research Volume: 1404 Pages: 10-20
  • Peer Reviewed
• [Presentation] Pancreatic islets cells receive axon terminals from melanocortin-4 receptor-expressing nodose ganglion cells in the mouse (2013)
  • Author(s): T. Tsumori, T. Oka, S. Yokota, Y. Yasui
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場(香川)
• [Presentation] Pancreatic islets cells receive axon terminals from melanocortin-4 receptor-expressing nodose ganglion cells in the mouse (2013)
  • Author(s): Toshiko Tsumori
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場（高松市）
• [Presentation] Tongue taste buds receive nerve terminals originating from melanocortin-4 receptor expressing neurons in the mouse geniculate and petrosal ganglia (2013)
  • Author(s): Toshiko Tsumori
  • Organizer: 第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経回路学会大会 合同大会
  • Place of Presentation: 国立京都国際会館（京都市）
• [Presentation] Axon terminals originating from melanocortin-4 receptor-expressing nodose gang lion cells form synapses with pancreatic endocrine cells in the mouse (2012)
  • Author(s): T. Tsumori, T. Oka, JG. Niu, Y. Yasui
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] Axon terminals originating from melanocortin-4 receptor-expressing nodose ganglion cells form synapses with pancreatic endocrine cells in the mouse (2012)
  • Author(s): Toshiko Tsumori
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Glutamatergic neurons in the lateral part of the periaqueductal gray innervateneurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat (2011)
  • Author(s): T. Oka, S. Yokota, T. Tsumori, JG. Niu, Y. Yasui
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Synaptic organization between melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve and enteric ganglia neurons in the mouse (2011)
  • Author(s): T. Tsumori, T. Oka, JG. Niu, Y. Yasui
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Glutamatergic neurons in the lateral part of the periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat (2011)
  • Author(s): 岡 達郎
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）