| Project/Area Number |
23790651
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KATANO Tayo 関西医科大学, 医学部, 講師 (60469244)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 疼痛の発生・増強機構 / プロテオミクス / コンディショナル KO / 神経障害性疼痛 / プロテオミクス解析 / ノックアウトマウス / KOマウス / 行動解析 |
|---|
| Research Abstract |
To clarify the role and functions of Neuropathic Pain RelatedProtein-A,-B (NPRP-A、NPRP-B) , we analyzed biological properties and pain responses after spared nerve injury (SNI) of NPRP-B using specific antibody and knock-out mice. NPRP-B is highly expressed in the central nervous system including spinal dorsal horn and especially enriched in synaptosomal fraction. NPRP-B exists as phosphorylated protein. In NPRP-B knock-out mice, mechanical allodynia is significantly reduced after SNIcompared with that in wild-type mice.
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