| Project/Area Number |
23790654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
SUZUKI Masami 独立行政法人国立がん研究センター, 研究所, 研究員 (80434182)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 疼痛 / 腹膜播種 / モルヒネ / ケモカイン / オピオイド受容体 / 脊髄後根神経節 / がん疼痛 / opioid 受容体 / substance P / モルヒネ抵抗性 |
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| Research Abstract |
In the present study, I developed a novel mouse model for abdominal pain due to cancerous peritonitis. Mice with peritoneal carcinomatosis exhibit hypersensitivity to mechanical stimulation and visceral pain-like behavior. In the current model, I observed a dramatic increase in the expression of substance P, but not chemokines, in the dorsal root ganglia (DRG) of mice with peritoneal dissemination, suggesting that the up-regulation of substance P may be responsible for the abdominal pain due to peritoneal carcinomatosis. Another key finding in the present study was that peritoneal dissemination decreased the expression of μ-opioid receptor (MOR) in the DRG. In relation to the down-regulation of MOR, the effect of morphine was less in tumor-bearing mice than that in inflammatory pain model mice. This newly developed model may be important for studying the pathogenesis of abdominal pain due to cancerous peritonitis.
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