Consideration of the strategy for prevention of cardiovascular disease from the perspective of fatty acid composition and catalytic enzyme.
| Project/Area Number |
23790656
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Gunma University |
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Principal Investigator |
MATSUI HIROKI 群馬大学, 保健学研究科, 助教 (20431710)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 心血管病 / 遊離脂肪酸 / メタボリックシンドローム / 予防医学 / 触媒酵素 / 脂肪酸分画 / 糖尿病 / 内臓肥満 / 心筋傷害 / 動脈硬化 / 飽和脂肪酸 / 不飽和脂肪酸 / 脂肪酸触媒酵素 |
|---|
| Research Abstract |
The clinical findings suggest that elevated plasma free fatty acids could be associated with acceleration of cardiovascular disease. However, little is known about the mechanism by which disturbance for the effect of fatty acid composition in heart or vessel results in cardiovascular diseases. We have focused on two fatty acid catalytic enzymes, Stearoyl-CoA desaturase 1 (SCD1), that catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated fatty acids (SFA), Elongase of long chain fatty acids 6 (Elovl6), that catalyzes the elongation of long-chain SFA and MUFA. Collectively, our results suggest that perturbation of fatty acid composition in heart and blood vessel leads to the onset and development of cardiovascular disease, and also suggest that SCD1 and Elovl6 as the novel protective and therapeutic target for cardiovascular disease.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting2013
Author(s)
Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M
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Journal Title
PLoS One
Volume: 14;8
Issue: 11
Pages: e79386-e79386
DOI
Related Report
Peer Reviewed
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[Journal Article] Attitudes toward interprofessional health care teams in undergraduate students and the alumni2013
Author(s)
Makino T, Shinozaki H, Hayashi K, Lee B, Matsui H, Kururi N, Kazama H, Ogawara H, Tozato F, Iwasaki K, Asakawa Y, Abe Y, Uchida Y, Kanaizumi S, Sakou K, Watanabe H
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Journal Title
J Interprof Care.
Volume: in press
Related Report
Peer Reviewed
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[Presentation] The role of Elovl6 in pulmonary fibrosis
Author(s)
Hiroaki Sunaga, Hiroki Matsui, Manabu Ueno, Toshitaka Maeno, Takashi Matsuzaka, Hitoshi Shimano, Masahiko Kurabayashi, Tomoyuki Yokoyama
Organizer
American Thoratic Society 2012 International Conference
Place of Presentation
サンフランシスコ（アメリカ合衆国）
Related Report
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[Presentation] 肺の線維化におけるElovl6の病態意義
Author(s)
須永 浩章, 松井 弘樹, 上野 学, 前野 敏孝, 竹村 仁男, 増渕 裕朗, 青木 史暁, 須賀 達夫, 松坂 賢, 島野 仁, 倉林 正彦, 横山 知行
Organizer
第52回日本呼吸器学会学術講演会
Place of Presentation
神戸国際会議場（兵庫県）
Related Report
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