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Relationship between surface potential of nanoparticle andtranslocation to brain via olfactory nerve

Research Project

Project/Area Number 23790659
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene
Research InstitutionKyoto University

Principal Investigator

MATSUI Yasuto  京都大学, 工学研究科, 講師 (50533501)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsナノ材料 / 衛生 / 細胞・組織 / 脳・神経 / ナノバイオ / ナノ粒子 / 細胞侵入 / ゼータ電位 / 表面修飾 / 量子ドット / 取り込み量
Research Abstract

Recent studies have shown that cellular uptake of nanoparticles depends on diameter, superficial area or surface modification. In this study, we examined that amounts of cellular uptake rely on it by measuring their zeta potential. We suspended 4 different surface modification fluorescent particles and measured their zeta potential and administered each of them to A549 cells, and employed confocal scanning laser microscopy. After thirty minute added particles to cells, we washed these cells three times and detected fluorescence by flow cytometer. Almost all the carboxylate particles invaded a cell and about 60 % aminated them also invaded. On the other hand, few non-modification particles were taken up.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Relationship between Surface Modifications of Nanoparticle and Invasion into Suspension Cells2011

    • Author(s)
      Matsui Y., Sakai N., Tsuda A. and YonedaM.
    • Journal Title

      J. Phys.: Conf. Ser

      Volume: 304 Pages: 12051-12051

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Exposure Assessment on Consumer Products Including Nanomaterials During Use and Disposal Process2013

    • Author(s)
      Yasuto Matsui
    • Organizer
      Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantum cellular uptake of nano-sized particles depending on physicochemical characters2012

    • Author(s)
      K. Nishioka, Y. Matsui, M. Yoneda
    • Organizer
      American Thoracic Society 2012
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Sensory Nerves around Pulmonary Alveoli in Mice and Translocation of Nanoparticles to Neuronal Cells2012

    • Author(s)
      Y. Matsui, N. Sakai, M. Yoneda, A. Tsuda
    • Organizer
      American Thoracic Society 2011
    • Place of Presentation
      Denver, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Quantitative Analysis About Cellular Uptake Of Nanoparticles Depending On Physicochemical Characters2012

    • Author(s)
      Yasuto Matsui
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] チャンバー法によるナノ材料を含む製品からのナノ材料の曝露評価2012

    • Author(s)
      松井 康人
    • Organizer
      リスク研究学会
    • Place of Presentation
      滋賀県彦根市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative Analysis About Cellular Uptake Of Nanoparticles Depending On Physicochemical Characters2012

    • Author(s)
      K. Nishioka, Y. Matsui, M. Yoneda
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] Synchrotron Micro-CT Imaging Of Olfactory Bulb In Rats Exposed Gold Nanoparticles By Inhalation2011

    • Author(s)
      N. Sakai, Y. Matsui, M. Yoneda, A. Tsuda
    • Organizer
      American Thoracic Society 2011
    • Place of Presentation
      Denver, USA
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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