| Project/Area Number |
23790664
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
|
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| Research Institution | Okayama University (2013)
Kagawa University (2011-2012) |
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Principal Investigator |
SAKANO Noriko 岡山大学, 医歯(薬)学総合研究科, 講師 (80574813)
|
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| Research Collaborator |
MIYATAKE Nobuyuki 香川大学, 医学部, 准教授 (30510705)
HIRAO Tomohiro 香川大学, 医学部, 教授 (20325335)
OGINO Keiki 岡山大学, 医歯薬学総合研究科, 教授 (70204104)
|
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 予防医学 / 酸化ストレス / 抗酸化 / 肥満 / IL-18 / MCP-4 / 運動 / 生活習慣病 |
|---|
| Research Abstract |
Serum IL-18 levels were higher in Japanese subjects with obesity than in those without. In addition, serum IL-18 levels were significantly and positively correlated with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is a biomarker of oxidative damage induced by DNA, and negatively correlated with plasma SOD, which is an antioxidant.
Serum MCP-4 levels in subjects with obesity were also higher than those without. However, those were negatively correlated with oxidative stress marker. Therefore, while the higher levels of MCP-4 linked to visceral fat accumulation; MCP-4 may reduce oxidant stress through increasing antioxidant potential.
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