| Project/Area Number |
23790666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Research Collaborator |
AOKI Yuka 札幌医科大学, 医学部, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 多発性骨髄腫 / エピジェネティクス / DNA メチル化 / リスク要因 / 反復配列 / LINE-1 / 多段階発がん |
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| Research Abstract |
In this study, we observed aberrant hypomethylation of LINE-1 and other repeated sequences in multiple myeloma, its association with genomic deletion, andthe association between hypomethylation and poor prognosis. In addition, it was indicated that LINE-1 sequences are dense in the commonly deleted legion and also usefulness of MBD-sequencing. We reported these results in Genome Medicine 2012;4:101. Our study suggested the potential of LINE-1 targeting strategy in clinical situation.
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