| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Diesel exhaust is a main airborne contaminant and includes many nanoparticles. Little studies reporting effects of nanoparticle-rich diesel exhaust (NR-DE) on liver have been conducted. In the present study, DNA microarray analysis showed that about 140 μg/m^3NR-DE for 1 month exposure caused the disruption of lipid homeostasis in rats. Additionally, exposure of NR-DE and filtered NR-DE, i.e. NR-DE without nanoparticles, increased hepatic fatty acids in mice. These results suggest that diesel exhaust induces the disturbance of lipid homeostasis and the main player exist in gas component in diesel exhaust.
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