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Development of "microRNA-regulating chemoprevention in cancer"

Research Project

Project/Area Number 23790670
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TOMOSUGI Mitsuhiro  京都府立医科大学, 医学部, プロジェクト研究員 (60533429)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌 / microRNA / 予防法開発 / 細胞周期停止 / RB / 予防 / 治療
Research Abstract

I searched for the food components that regulated microRNA expression. As a result from flow cytometry analysis, flavone was found, using RB inactivated cancer cells.In mutated RB cell line, flavone increased phosphorylated RB family proteins p130 and p107. Flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G1 arrest by flavone.These results suggested that food component could control expression of microRNA invivo. The research of miR-34a regulated by flavone might realize “microRNA-regulating chemoprevention in cancer”.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor2012

    • Author(s)
      Tomosugi M、Sowa Y、Yasuda S、Tanaka R、te Riele H、Ikawa H、Koyama M、Sakai T
    • Journal Title

      Cancer Science

      Volume: 103 Pages: 2139-2143

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor2012

    • Author(s)
      Tomosugi M, Sowa Y, Yasuda S, Tanaka R, te Riele H, Ikawa H, Koyama M, Sakai T
    • Journal Title

      Cancer Sci.

      Volume: Vol. 103、 No. 12 Issue: 12 Pages: 2139-2143

    • DOI

      10.1111/cas.12012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラボンや分子標的薬による RB 非依存的な G1 期停止の誘導2013

    • Author(s)
      友杉充宏、曽和義広、安田周祐、田中良一、井川陽菜、小山真、酒井敏行
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      石川県金沢市金沢大学鶴間キャンパス
    • Year and Date
      2013-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] RB independent G1-phase arrest by molecular-targeting agents and flavone (フラボンや分子標的薬による RB 非依存的な G1 期停止の誘導)2012

    • Author(s)
      友杉充宏、曽和義広、安田周祐、小山真、酒井敏行
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市ロイトン札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] フラボンによる RB 非依存的 G1 期停止の誘導2011

    • Author(s)
      友杉充宏、曽和義広、酒井敏行
    • Organizer
      がん予防大会 2011 京都
    • Place of Presentation
      京都府京都市京都府立医科大学図書館ホール
    • Year and Date
      2011-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] フラボンや分子標的薬によるRB非依存的なG1期停止の誘導

    • Author(s)
      友杉充宏、曽和義広、安田周祐、小山真、酒井敏行
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] フラボンや分子標的薬によるRB非依存的なG1期停止の誘導

    • Author(s)
      友杉充宏、曽和義広、酒井敏行
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学鶴間キャンパス
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/k/pubmed/

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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