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A study on the association between urinary aluminum concentration and pre-clinical findings among aluminum handling and non-handling workers

Research Project

Project/Area Number 23790672
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene
Research InstitutionJichi Medical University

Principal Investigator

OGAWA Masanori  自治医科大学, 医学部, 講師 (70525451)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアルミニウム / 毒性 / 前臨床的指標 / 生物学的モニタリング
Research Abstract

In order to estimate the toxicity of aluminum to humans, we measure the aluminum concentration in urine among the aluminum handling and non-handling workers and investigate the relationships between the urinary aluminum concentration and the pre-clinical findings. The aluminum concentration in urine ranges from 5.4-55.1ug/g cre in the aluminum handling workers and the aluminum concentration in urine ranges from 5.6-15.6ug/g cre in the non-handling workers. There are significant differences between them. There are no significant differences in the pre-clinical findings. Although the excretion of aluminum in urine increases in aluminun handling workers, it is demonstrated that aluminum is not harmful to humans, at least in case that aluminum in urine is below 55ug/g cre.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2012 Other

All Presentation (5 results)

  • [Presentation] アルミニウム作業者および非作業者における尿中アルミニウム濃度と前臨床的所見の検討2013

    • Author(s)
      小川真規・香山不二雄
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Year and Date
      2013-05-15
    • Related Report
      2013 Final Research Report
  • [Presentation] アルミニウム鋳造作業者における尿中アルミニウム濃度と前臨床的所見の検討2012

    • Author(s)
      小川真規
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] A study of exposures and pre-clinical findings among the aluminum casting workers2012

    • Author(s)
      Masanori Ogawa, Fujio Kayama
    • Organizer
      Society of Toxicology
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] アルミニウム作業者および非作業者における尿中アルミニウム濃度と前臨床的所見の検討

    • Author(s)
      小川真規、香山不二雄
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルミニウム作業者および非作業者における尿中アルミニウム濃度と前臨床的所見の検討

    • Author(s)
      小川真規
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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