Comprehensive screening of promoting factors involved in carcinogenesis and progression on the basis of DNA demethylation in Annexin A8 gene in pancreatic cancers.
| Project/Area Number |
23790675
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
HATA Harumi 昭和大学, 医学部, 助教 (00396441)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | Annexin / メチル化 / アネキシン / 膵癌 |
|---|
| Research Abstract |
We first investigated the functional role of ANXA8 in pancreatic cancer cell lines. We clarified that ANXA8 elevated transcriptional activation of HIF-1a, and that changes in expression levels of ANXA8 were associated with cell viability, migration, and resistance against hypoxic conditions in pancreatic cancer cells. Using the construct harboring the promoter sequences of ANXA8 upstream of the luciferase gene, we exhaustively explored promoting factors involved in carcinogenesis and progression on the basis of DNA demethylation in ANXA8 gene in pancreatic cancers.
|
Report
(3 results)
Research Products
(4 results)
-
-
[Journal Article] Exclusive expression of VMAT2 in noradrenergic neurons increases viability of homozygous VMAT2 knockout mice2013
Author(s)
Ohara A, Kasahara Y, Yamamoto H, Hata H, Kobayashi H, Numachi Y, Miyoshi I, Hall FS, Uhl GR, Ikeda K, Sora I
-
Journal Title
Biochem Biophys Res Commun
Volume: 432
Issue: 3
Pages: 526-532
DOI
Related Report
Peer Reviewed
-
-
