Comprehensive screening of promoting factors involved in carcinogenesis and progression on the basis of DNA demethylation in Annexin A8 gene in pancreatic cancers.

Research Project

Project/Area Number	23790675
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene
Research Institution	Showa University
Principal Investigator	HATA Harumi 昭和大学, 医学部, 助教 (00396441)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	Annexin / メチル化 / アネキシン / 膵癌
Research Abstract	We first investigated the functional role of ANXA8 in pancreatic cancer cell lines. We clarified that ANXA8 elevated transcriptional activation of HIF-1a, and that changes in expression levels of ANXA8 were associated with cell viability, migration, and resistance against hypoxic conditions in pancreatic cancer cells. Using the construct harboring the promoter sequences of ANXA8 upstream of the luciferase gene, we exhaustively explored promoting factors involved in carcinogenesis and progression on the basis of DNA demethylation in ANXA8 gene in pancreatic cancers.

Report

(3 results)