| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
N-EtFOSE (N-ethylperfluorooctane sulfonate amide ethanol) is one of the materials for PFOS synthesis, it is not well known about its influences. In this study, we conducted in utero and prepubertal exposures to N-EtFOSE. In utero N-EtFOSE exposure alters the placental gene expressions and the patterns of these gene expressions are different between males and females. Prepubertal exposures to N-EtFOSE resulted in the serum testosterone levels and the altering gene expressions involved in testosterone synthesis in male rats, and increasing rate of abnormal estrus cycles and the altering gene expressions involved in estrogen synthesis in female rats.
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