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Circadian rhythms and endogenous melatonin in childhood in relation to growth and obesity

Research Project

Project/Area Number 23790688
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Public health/Health science
Research InstitutionGifu University

Principal Investigator

WADA Keiko  岐阜大学, 医学系研究科, 助教 (00532673)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords疫学 / サーカディアンリズム / メラトニン / 生活習慣 / 小児
Research Abstract

Subjects were about 600 preschoolers and 2,500 elementary school students. Information related to children’s height, weight, birth weight and lifestyles including sleep, light exposure at night, diet, physical activity, behavior problems, the time in front of screens, passive smoking, and mother’s anthropometric and psychological characteristics was obtained from parent or self -administered questionnaires. At the same time, parents provided their children’s first-void morning urine for measurements of 6-sulfatoxymelatonin. Among some children, overweight and metabolic syndrome were diagnosed by health checkup. We assessed the association of sex, age, body mass, sex steroid hormones, and lifestyle factors with the levels of melatonin in children. We also aimed to investigate whether endogenous melatonin was associated with the parameters of sleep and behavioral problems.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2013 2012 2011

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (9 results)

  • [Journal Article] Associations of endogenous melatonin and sleep-related factors with behavioral problems in preschool Japanese children2013

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Watanabe K, Ando K, Nagata C
    • Journal Title

      Ann Epidemiol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children2013

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Masue T, Watanabe K, Ando K, Nagata C
    • Journal Title

      Ann Epidemiol

      Volume: 23(2) Pages: 60-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children2013

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Masue T, Watanabe K, Ando K, Nagata C
    • Journal Title

      Ann Epidemiol.

      Volume: 23(2) Issue: 2 Pages: 60-65

    • DOI

      10.1016/j.annepidem.2012.11.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light exposure at night, sleep duration and sex hormone levels in pregnant Japanese women.2012

    • Author(s)
      Wada K, Nagata C, Nakamura K, Iwasa S, Shiraki M, Shimizu H
    • Journal Title

      Endocr J

      Volume: 59(5) Pages: 393-8

    • NAID

      10030816363

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women2012

    • Author(s)
      Tsuji M, Tamai Y, Wada K, Nakamura K, Hayashi M, Takeda N, Yasuda K, Nagata C
    • Journal Title

      Cancer Causes Control

      Volume: 23(5) Pages: 683-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of birth weight and physical activity with sex steroids in preschool Japanese children2012

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Masue T, Ando K, Nagata C
    • Journal Title

      Cancer Causes Control

      Volume: 23(2) Pages: 231-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seaweed intake and urinary sex hormone levels in preschool Japanese children2012

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Watanabe K, Ando K, Nagata C
    • Journal Title

      Cancer Causes Control

      Volume: 23(2) Pages: 239-44

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship of intake of plant-based foods with 6-n-propylthiouracil sensitivity and food neophobia in Japanese preschool children.2012

    • Author(s)
      Tsuji M, Nakamura K, Tamai Y, Wada K, Sahashi Y, Watanabe K, Ohtsuchi S, Ando K, Nagata C
    • Journal Title

      Eur J Clin Nutr

      Volume: 66(1) Pages: 47-52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of urinary 6-sulfatoxymelatonin with biomarkers related to cardiovascular disease in Japanese women2012

    • Author(s)
      Masue T, Wada K, Hayashi M, Takeda N, Yasuda K, Deguchi T, Nagata C
    • Journal Title

      Metabolism

      Volume: 61(1) Pages: 70-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of physical activity and diet with the onset of menopause in Japanese women2012

    • Author(s)
      Nagata C, Wada K, Nakamura K, Tamai Y, Tsuji M, Shimizu H
    • Journal Title

      Menopause

      Volume: 19(1) Pages: 75-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light exposure at night, sleep duration and sex hormone levels in pregnant Japanese women2012

    • Author(s)
      Wada K, Nagata C, Nakamura K, Iwasa S, Shiraki M, Shimizu H
    • Journal Title

      Endocr J.

      Volume: 59(5) Pages: 393-398

    • NAID

      10030816363

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of birth weight and physical activity with sex steroids in preschool Japanese children2012

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Masue T, Ando K, Nagata C
    • Journal Title

      Cancer Causes Control

      Volume: 23(2) Pages: 231-8

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of vitamin B12 and folic acid is associated with lower blood pressure in Japanese preschool children2011

    • Author(s)
      Tamai Y, Wada K, Tsuji M, Nakamura K, Sahashi Y, Watanabe K, Yamamoto K, Ando K, Nagata C
    • Journal Title

      Am J Hypertens

      Volume: 24(11) Pages: 1215-21

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seaweed intake and blood pressure levels in healthy pre-school Japanese children2011

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Sahashi Y, Watanabe K, Ohtsuchi S, Yamamoto K, Ando K, Nagata C
    • Journal Title

      Nutr J

      Volume: 10 Pages: 83-83

    • NAID

      120006341963

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validity and reproducibility of food frequency questionnaire in Japanese children aged 6 years2011

    • Author(s)
      Sahashi Y, Tsuji M, Wada K, Tamai Y, Nakamura K, Nagata C
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo)

      Volume: 57(5) Pages: 372-6

    • NAID

      130002103084

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of body size and reproductive factors with circulating levels of sex hormones and prolactin in premenopausal Japanese women2011

    • Author(s)
      Nagata C, Wada K, Nakamura K, Hayashi M, Takeda N, Yasuda K
    • Journal Title

      Cancer Causes Control

      Volume: 22(4) Pages: 581-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seaweed intake and blood pressure levels in healthy pre-school Japanese children2011

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Sahashi Y, Watanabe K, Ohtsuchi S, Yamamoto K, Ando K, Nagata C
    • Journal Title

      Nutrition Journal

      Volume: 10(1) Pages: 83-83

    • NAID

      120006341963

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 幼児期のテレビ視聴時間と行動的問題の関連2013

    • Author(s)
      和田恵子、中村こず枝、辻美智子、玉井裕也、渡辺香織、 大土早紀子、山本景子、安藤京子、永田知里
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 幼児期の尿中メラトニンと体格・生活環境要因との関連2012

    • Author(s)
      和田恵子、中村こず枝、玉井裕也、辻美智子、渡辺香織、大土早紀子、山本景子、安藤京子、永田知里
    • Organizer
      日本がん疫学・分子疫学研究会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 幼児期の行動的問題と睡眠習慣、内因性メラトニンとの関連2012

    • Author(s)
      和田恵子、中村こず枝、辻美智子、玉井裕也、渡辺香織、大土早紀子、山本景子、安藤京子、永田知里
    • Organizer
      日本疫学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 大豆接種と乳がんリスクとの関連:高山スタディ2012

    • Author(s)
      和田恵子、中村こず枝、辻美智子、玉井裕也、永田知里
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exposure to tobacco smoke from husband and breast cancer risk in Japanese women.2012

    • Author(s)
      Wada K, Nakamura K, Tamai Y, Tsuji M, Kawachi T and Nagata C
    • Organizer
      Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research
    • Place of Presentation
      Anaheim (USA),
    • Related Report
      2012 Annual Research Report
  • [Presentation] 幼児期の行動的問題と睡眠習慣、内因性メラトニンとの関連2012

    • Author(s)
      和田恵子、中村こず枝、辻美智子、玉井裕也、渡辺香織、大土早紀子、山本景子、安藤京子、永田知里
    • Organizer
      日本疫学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Associations between seaweed intake and sex steroids in preschool Japanese children2011

    • Author(s)
      Keiko Wada, Kozue Nakamura, Michiko Tsuji, Yuya Tamai, Chisato Nagata
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 幼児における出生体重と尿中性ホルモンの関連2011

    • Author(s)
      和田恵子、中村こず枝、辻美智子、玉井裕也、渡辺香織、大土早紀子、山本景子、安藤京子、永田知里
    • Organizer
      がん予防大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Associations between seaweed intake and sex steroids in preschool Japanese children2011

    • Author(s)
      Keiko Wada, Kozue Nakamura, Michiko Tsuji, Yuya Tamai, Chisato Nagata
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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