| Project/Area Number |
23790711
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 動脈硬化 / 炎症 / エイコサペンタエン酸 / ドコサヘキサエン酸 / 腎機能 / シスタチン C / シスタチンＣ / 生活習慣 / 脂肪酸分画 |
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| Research Abstract |
Among general population in Kobe city, high-sensitivity C-reactive protein (hs-CRP) showed significant positive association with cardio-ankle vascular index (CAVI) after adjustment for age, sex and other classical cardiovascular risk factors. This result suggests that inflammation is associated with atherosclerosis which relates to renal dysfunction in general population, either. Then we investigated the association between renal function and n-3 polyunsaturated fatty acids such as EPA and DHA which are known to have anti-inflammation effects, among general population in Sasayama city. EPA and DHA showed positive relationship with glomerular filtration rate estimated by cystatin C. Thus fish intake could prevent renal dysfunction in general population.
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