| Project/Area Number |
23790713
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 健康診断 / 疫学 / アセチルグルコサミニダーゼ / 死亡率 / 前向き研究 / 社会医学 |
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| Research Abstract |
Elevated serum N-acetyl-s-D-Glucosaminidase (NAG) activity is related to various cardiovascular risk factors and is a predictor of incident hypertension. Urinary but not serum NAG activity was an important prognostic marker in renal diseases. We measured serum NAG activities in 1,080 apparently healthy subjects (aged over 20 years) in 1982. Importantly, we reported 17 years ago that high serum NAG activity was a predictor of future development of hypertension in a general population. We hypothesized that elevated serum NAG activity would be a predictor of cerebro-cardiovascular death in community-based cohort study. Accordingly, we examined whether the serum NAG activity would predict 28-year cerebro-cardiovascular and all-cause deaths in the same population. The hazard ratio of all-cause death in the highest quartile of serum NAG (?14.0 IU/L) vs. the lowest quartile after adjustment for confounding factors was 1.35 (95% CI,1.02-1.83). On the other hand, no significant associatins were found between NAG activities and cardiovascular mortality. In conclusion, the present study suggests that the serum NAG activity is an independent predictor of all-cause mortality in a general population.
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