Plasma Endothelin-1 Level Is a Predictor of 10-Year Mortality in a General Population
Project/Area Number |
23790714
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Public health/Health science
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Research Institution | Kurume University |
Principal Investigator |
YOKOI Kanako 久留米大学, 医学部, 助教 (80569385)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 疫学 / エンドセリン / 死亡率 / 追跡理 / エンドセリン-1 / 前向き研究 / 社会医学 |
Research Abstract |
Plasma ET-1 level is a predictor of mortality in patients with several types of cancers. However, all previous mortality data have been derived from patients with existing pathological cardiovascular disease and malignancies. Accordingly, we examined whether the plasma ET-1 level would predict 10-year cardiovascular, cancer and all-cause deaths in a general population. This is the first report demonstrating that the plasma ET-1 level is a predictor of 10-year mortality in subjects without apparent cardiovascular disease or malignancies in the general population.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] New computer model for prediction of individual 10-yearmortality on the basis of conventional atherosclerotic risk factors.2013
Author(s)
Ogata K, MiyamotoT, Adachi H, Hirai Y, Enomoto M, Fukami A, Yokoi K, Kasahara A, Tsukagawa E, Yoshimura A, Obuchi A, Nakamura S, Imaizumi T.
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Journal Title
Atherosclerosis.
Volume: 227
Pages: 159-164
Related Report
Peer Reviewed
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[Journal Article] High serum N-acetyl- β -d-glucosaminidase activity is predictor of 28-year mortality in a population of community-dwelling Japanease ? the Tanushimaru study.2013
Author(s)
Yoshikawa K, Adachi H, Hirai Y, Enomoto M, Fukami A, Ogata K, Tsukagawa E, Kasahara A, Yokoi K, Okina N, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T.
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Journal Title
J Am Geriatr Soc.
Volume: 61(3)
Issue: 3
Pages: 467-468
DOI
Related Report
Peer Reviewed
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[Journal Article] High level of plasma remnant-like particle cholesterol may predispose to development of hypertention in normotensive subjects.2013
Author(s)
Kasahara A, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshikawa K, Esaki E, Yokoi K, Ogata K, Tsukagawa E, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T.
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Journal Title
Am J Hypertens.
Volume: 26(6)
Issue: 6
Pages: 793-798
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population.2012
Author(s)
Otsuka M, Adachi H, Jacobs DR Jr, Hirai Y, Enomoto M, Fukami A, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Kumagai E, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Ohbu K, Imaizumi T.
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Journal Title
J Epidemiol.
Volume: 22(5)
Pages: 395-401
NAID
Related Report
Peer Reviewed
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[Journal Article] LDL-C/HDL-C ratio predicts carotid intima-media thickness progression better than HDL-C or LDL-C alone2011
Author(s)
Enomoto M, Adachi H, Hirai Y, Fukami A, Satoh A, Otsuka M, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Kumagai E, Ogata K, Kasahara A, Tsukagawa E, Yokoi K, Ohbu-Murayama K, Imaizumi T.
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Journal Title
J Lipids. 2011
Volume: 2011
Pages: 549137-549137
DOI
Related Report
Peer Reviewed
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[Presentation] High level of plasma Endothelin-1 is a predictor of 10-year mortality in a general population: The Tanushimaru Study2011
Author(s)
Yokoi K, Adachi H, Hirai Y, Enomoto M, Fukami A, Otsuka M, Miyamoto T, Najo Y, Yoshikawa K, Esaki E, Kumagai E, Ogata K, Kasahara A, Tsukagawa E, Ohbu K, Imaizumi T
Organizer
American Heart Association
Place of Presentation
USA、オーランド
Related Report