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A proposal for the cutoff point of HbA1c for the risk assessment of diabetic retinopathy in the Japanese population

Research Project

Project/Area Number 23790717
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Public health/Health science
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

MATSUSHITA Yumi  独立行政法人国立国際医療研究センター, その他部局等, その他 (50450599)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords疫学 / 糖尿病
Research Abstract

The relationship between HbA1c and diabetic retinopathy is expected to differ based on race and the HbA1c threshold for Japanese has not been determined yet. In this study, we aimed to provide data on the relationship between HbA1c and retinopathy and assessed the accuracy of the proposed HbA1c cutoff from ADA (6.5%) for detecting diabetic retinopathy in a Japanese population.
The ability to detect the diabetic retinopathy was almost same in both cross-sectional and longitudinal study, thus it will be possible to diagnose DM by HbA1c only. The cut-off level of HbA1c (6.5%) may be appropriate for Japanese population.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (53 results)

All 2014 2013 2012 2011

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (21 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] Secretory units of islets in transplantation index (SUIT)is a useful predictor of insulin requirement in Japanese type 2 diabetic patients2014

    • Author(s)
      Iwata M, Matsushita Y, Fukuda K, et al.(他9名)
    • Journal Title

      J Diabetes Investigation

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] How can waist circumference predict the body composition?2014

    • Author(s)
      Matsushita Y, Nakagawa T, Shinohara M, et al.(他5名)
    • Journal Title

      Diabetology&Metabolic Syndrome

      Volume: vol.6, No.1 Pages: 11-11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin and visceral fat associate with cardiovascular risk factors2014

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, et al.(他7名)
    • Journal Title

      Obesity (Silver spring)

      Volume: vol.22, No.1 Pages: 287-291

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretory units of islets in transplantation index (SUIT)is a useful predictor of insulin requirement in Japanese type 2 diabetic patients.2014

    • Author(s)
      Iwata M, Matsushita Y, Fukuda K, Wakura T, Okabe K, Koshimizu Y, Fukushima Y, Kobashi C, Yamazaki Y, Honoki H, Suzuki H, Tobe K
    • Journal Title

      J Diabetes Investigation.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How can waist circumference predict the body composition?2014

    • Author(s)
      Matsushita Y, Nakagawa T, Shinohara M, Yamamoto S, Takahashi Y, Mizoue T, Yokoyama T, Noda M
    • Journal Title

      Diabetology & Metabolic Syndrome.

      Volume: 6 Pages: 11-11

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin and visceral fat associate with cardiovascular risk factors.2014

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, Kato T, Ouchi T, Kikuchi N, Takahashi Y, Yokoyama T, Mizoue T, Noda M
    • Journal Title

      Obesity (Silver Spring).

      Volume: 22 Pages: 287-291

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver2013

    • Author(s)
      Okumura A, Unoki-Kubota H, Matsushita Y, et al.(他4名)
    • Journal Title

      Biosci Trends

      Volume: vol.7, No.6 Pages: 279-283

    • NAID

      130003397274

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aging attenuates the association of central obesity with the accumulation of metabolic risk factors when assessed using the waist circumference measured at the umbilical level (the Japanese standard method)2013

    • Author(s)
      Okazawa T, Iwata M, Matsushita Y, et al.(他5名)
    • Journal Title

      Nutr Diabetes

      Volume: vol.3 Pages: 96-96

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of longitudinal changes in visceral fat area on incidence of metabolic risk factors : the Hitachi Health Study2013

    • Author(s)
      Matsushita Y, Nakagawa T,Yamamoto S, et al.(他4名)
    • Journal Title

      Obesity (Silver spring)

      Volume: vol.21,No.10 Pages: 2126-2129

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short sleep duration in association with CT-scanned abdominal fat areas : the Hitachi Health Study2013

    • Author(s)
      Yi S, Nakagawa T, Yamamoto S, Mizoue T, Takahashi Y, Noda M, Matsushita Y
    • Journal Title

      International Journal of Obesity

      Volume: vol.37,No.1 Pages: 129-134

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver.2013

    • Author(s)
      Okumura A, Unoki-Kubota H, Matsushita Y, Shiga T, Moriyoshi Y, Yamagoe S, Kaburagi Y
    • Journal Title

      Biosci Trends.

      Volume: 7 Pages: 276-283

    • NAID

      130003397274

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging attenuates the association of central obesity with the accumulation of metabolic risk factors when assessed using the waist circumference measured at the umbilical level (the Japanese standard method).2013

    • Author(s)
      Okazawa T, Iwata M, Matsushita Y, Kamura Y, Kato H, Okazawa S, Kigawa M, Tobe K
    • Journal Title

      Nutr Diabetes.

      Volume: 3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of longitudinal changes in visceral fat area on incidence of metabolic risk factors: the Hitachi Health Study.2013

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, Takahashi Y, Yokoyama T, Mizoue T, Noda M
    • Journal Title

      Obesity (Silver Spring).

      Volume: 21 Pages: 2126-2129

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of longitudinal changes in visceral fat area on incidence of metabolic risk factors: the Hitachi Health Study.2013

    • Author(s)
      Y Matsushita
    • Journal Title

      Obesity

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adiponectin and visceral fat associate with cardiovascular risk factors.2013

    • Author(s)
      Y Matsushita
    • Journal Title

      Obesity

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and C-peptide concentrations in a Japanese working population2012

    • Author(s)
      Akter S, Nanri A, Yi S, Pham NM, Kurotani K, Kimura Y, Matsushita Y, Mizoue T
    • Journal Title

      Nutrition

      Volume: vol.28,No9 Pages: 29-35

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depressive symptoms and oxidative DNA damage in Japanese municipal employees2012

    • Author(s)
      Yi S, Nanri A, Matsushita Y, et al.(他3名)
    • Journal Title

      Psychiatry Res

      Volume: vol.200,No.2-3 Pages: 318-322

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of six months lifestyle intervention in Japanese men with metabolic syndrome : randomized controlled trial2012

    • Author(s)
      Nanri A, Tomita K, Matsushita Y, et al.(他5名)
    • Journal Title

      J Occup Health

      Volume: vol.54, No.3 Pages: 215-222

    • NAID

      10030318499

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=22790524

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of longitudinal changes in visceral fat area and other anthropometric indices to the changes in metabolic risk factors in Japanese men : The Hitachi Health Study2012

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, et al.(他4名)
    • Journal Title

      Diabetes Care

      Volume: vol.35,No.5 Pages: 1139-1143

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women2012

    • Author(s)
      Poudel-Tandukar K, Sato M, Ejima Y, Nanri A, Matsushita Y, Imaizumi K, Mizoue T
    • Journal Title

      Atherosclerosis

      Volume: vol.220, No.2 Pages: 520-524

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visceral fat area cutoff for the detection of multiple risk factors of metabolic syndrome in Japanese : The Hitachi Health Study2012

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, (他4名)
    • Journal Title

      Obesity

      Volume: vol.20,No.8 Pages: 1744-1749

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visceral fat area cutoff for the detection of multiple risk factors of metabolic syndrome in japanese:The Hitachi Health Study.2012

    • Author(s)
      Y Matsushita
    • Journal Title

      Obesity

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of longitudinal Changesin visceral fat area and otheranthropometric indices to the changes in metabolic risk factors in japanese men.2012

    • Author(s)
      Y Matsushita
    • Journal Title

      Diabetes Care

      Volume: 35 Pages: 1139-1143

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between serum ferritin concentrations and depressive symptoms in Japanese municipal employees2011

    • Author(s)
      Yi S, Nanri A, Poudel-Tandukar K, Nonaka D, Matsushita Y, Hori A, Mizoue T
    • Journal Title

      Psychiatry Res

      Volume: vol.189, No.3 Pages: 368-372

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eating behavior in relation to prevalence of overweight among Japanese men2011

    • Author(s)
      Kimura Y, Nanri A, Matsushita Y, et al.(他2名)
    • Journal Title

      Asia Pac J Clin Nutr

      Volume: vol.20,No.1 Pages: 29-34

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=21393107

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic syndrome and depressive symptoms among Japanese men and women2011

    • Author(s)
      Kimura Y, Matsushita Y, Nanri A, et al.(他1名)
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: vol.16, No.6 Pages: 363-368

    • NAID

      10030211547

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of smoking cessation with visceral fat area and prevalence of metabolic syndrome in men : the Hitachi Health Study2011

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, et al.(他3名)
    • Journal Title

      Obesity

      Volume: vol.19,No.3 Pages: 647-651

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Effect of longitudinal changes in visceral fat area on incidence of metabolic risk factors2013

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoto S, et al.(他4名)
    • Organizer
      Asia-Pacific Diabetes and Obedity Study Group (APDO) symposium 2013 Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] アディポネクチンおよび内臓脂肪と心血管リスクファクターの関連2013

    • Author(s)
      松下由実,中川徹,山本修一郎, 他3名
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] LECT2は肥満と脂肪肝の予測因子となりうるか2013

    • Author(s)
      奥村彰規,久保田浩之,松下由実, 他3名
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 2型糖尿病患者における内因性インスリン分泌の指標による治療選択と将来の治療効果予測への有効性2013

    • Author(s)
      福田一仁,岩田実,和倉健朗,松下由実,岡部圭介,小清水由紀子,石木学,薄井勲,戸邉一之
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Leukocyte cell-derived chemotaxin 2は新規の肥満関連因子である2013

    • Author(s)
      奥村彰規,久保田浩之,松下由実, 他3名
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 腹部肥満とメタボリック症候群の危険因子との関連における加齢の影響2013

    • Author(s)
      岡澤光代,岩田実,加村裕,戸邉一之,加藤弘巳,松下由実
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肥満症の成因と疫学 成因のコントロールによる効果的な予防 食習慣・食環境2013

    • Author(s)
      松下由実
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effect of longitudinal changes in visceral fat area on incidence of metabolic risk factors.2013

    • Author(s)
      Yumi Matsushita, Toru Nakagawa, Shuichiro Yamamoto, Yoshihiko Takahashi, Tetsuji Yokoyama, Tetsuya Mizoue, Mitsuhiko Noda
    • Organizer
      Asia-Pacific Diabetes and Obedity Study Group (APDO) symposium 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Visceral Fat Area Cutoff for the Detection of Multiple Risk Factors of Metabolic Syndrome in Japanese : The Hitachi Health Study2012

    • Author(s)
      Matsushita Y, Nakagawa T, Yamamoyo S, et al.(他4名)
    • Organizer
      16th International Congress of Dietetics in Sydney, Australia
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] 心血管リスク因子保有数が急激に上昇する腹囲の性別・年齢別の検討2012

    • Author(s)
      岡澤光代,加村裕,岩田実,戸邉一之,加藤弘巳,松下由実
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 体格指数の変化がメタボリックシンドロームの各要因の変化に及ぼす影響;日立健康研究2012

    • Author(s)
      松下由実,中川徹,山本修一郎, 他3名
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 血中アディポネクチン値及び空腹時インスリン値を利用した、糖尿病発症予測日立健康研究から2012

    • Author(s)
      山本修一郎,松下由実,中川徹, 他2名
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺気腫に対するアディポネクチンの防御作用2012

    • Author(s)
      中田博文,松下由実,草野涼, 他3名
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] インターネットを介した減量支援の実施状況2012

    • Author(s)
      中川徹,起由美,色川正貴,松下由実
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Final Research Report
  • [Presentation] はらすまダイエットプログラム参加者の心理的変化の検討2012

    • Author(s)
      大川未央,中川徹,久保田純,松下由実
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Final Research Report
  • [Presentation] 体格指数の変化がメタボリックシンドロームの各要因の変化に及ぼす影響;日立健康研究2012

    • Author(s)
      松下由実
    • Organizer
      日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 血中アディポネクチン値及び空腹時インスリン値を利用した、糖尿病発症予測 日立健康研究から2012

    • Author(s)
      松下由実
    • Organizer
      日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] The Cutoff Levels of Waist Circumference for Predicting the Presence of the Clustering of Metabolic Risk Factors in some Asian Populations2011

    • Author(s)
      Matsushita Y, Kishimoto M, Noda M, et al.(他9名)
    • Organizer
      The 21^<st> World Diaberes Congress
    • Place of Presentation
      Dubai
    • Related Report
      2013 Final Research Report
  • [Presentation] メタボリックシンドロームのリスク重積検出の内臓脂肪面積カットオフ値の性・年齢別検討-日立健康研究2011

    • Author(s)
      松下由実,中川徹,山本修一郎, 他4名
    • Organizer
      第58回日本栄養改善学会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] メタボリックシンドロームのリスク重積検出の内臓脂肪面積カットオフ値の性・年齢別検討-日立健康研究2011

    • Author(s)
      松下由実
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] The Cutoff Levels of Waist Circu-mference for Predicting the presence of the Clustering of Metabolic Risk Factors in some Asian Populations2011

    • Author(s)
      Y.Matsushita
    • Organizer
      World Diabetes Congress Dubai
    • Place of Presentation
      Dubai
    • Related Report
      2011 Research-status Report
  • [Book] これからの公衆衛生学社会・環境と健康第5章1.②健康日本21(第2次)2013

    • Author(s)
      松下由実, 他
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] これからの公衆衛生学  社会・環境と健康2013

    • Author(s)
      松下由実
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] これからの公衆衛生学 社会・環境と健康2013

    • Author(s)
      松下由実
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2012 Research-status Report
  • [Book] 糖尿病学2011 19.内臓脂肪面積とメタボリックリスクファクターの集積:the Hitachi Health Studyから2011

    • Author(s)
      松下由実, 他
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 糖尿病学20112011

    • Author(s)
      松下由実
    • Total Pages
      6
    • Publisher
      診断と治療社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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