Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Research Abstract |
HRD1 is reported to be involved in the pathogenesis of neurodegenerative disorders by its ubiquitin ligase activity. In the present study, we examine whether it is possible for HRD1 to be the marker of brain dysfunction. We found that HRD1 and related molecules are induced in the in vitromodels of neurodegenerative disorders. Furthermore, we demonstrated that zonisamide, an antiepileptic agent, up-regulates HRD1 and suppresses neuronal cell death.
|