Elucidation of transcriptional regulation mechanism of ABO gene based on chromatin remodeling.
| Project/Area Number |
23790723
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
SANO Rie 群馬大学, 大学院・医学系研究科, 助教 (70455955)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ABO / 転写調節機構 / ABO式血液型 / 転写調節 / ルシフェラーゼアッセイ / ABO式血液型変異型Bm型 |
|---|
| Research Abstract |
An erythroid cell-specific regulatory element has been identified in the first intron of ABO using luciferase reporter assays with K562 cells. The erythroid cell-specific regulatory activity of the element was dependent upon GATA-1 binding. In addition, partial deletion of intron 1 including the element was observed in genomic DNAs obtained from 111 Bm and ABm individuals.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Mutation of the GATA site in the erythroid cell-specific regulatory element of the ABO gene in a Bm subgroup individual.2013
Author(s)
Nakajima T, Sano R, Takahashi Y, Kubo R, Takahashi K, Kominato Y, Tsukada J, Takeshita H, Yasuda T, Uchikawa M, Isa K, Ogasawara K.
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Journal Title
Transfusion.
Volume: in press
Related Report
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[Journal Article] Expression of ABO blood-group genes is dependent upon an erythroid cell-specific regulatory element that is deleted in persons with the Bm phenotype2012
Author(s)
Sano R, Nakajima T, Takahashi K, Kubo R, Kominato Y, Tsukada J, Takeshita H, Yasuda T, Ito K, Maruhashi T, Yokohama A, Isa K, Ogasawara K, Uchikawa M
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Journal Title
Blood
Volume: 119
Pages: 5301-10
Related Report
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[Journal Article] Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity2012
Author(s)
Kimura-Kataoka K, Yasuda T, Fujihara J, Toga T, Ono R, Otsuka Y, Ueki M, Iida R, Sano R, Nakajima T, Kominato Y, Kato H, Takeshita H
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Journal Title
Electrophoresis
Volume: 33
Pages: 2852-58
Related Report
Peer Reviewed
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[Journal Article] Expression of ABO blood-group genes is dependent upon an erythroid cell-specific regulatory element that is deleted in persons with the Bm phenotype.2012
Author(s)
Sano R, Nakajima T, Takahashi K, Kubo R, Kominato Y, Tsukada J, Takeshita H, Yasuda T, Ito K, Maruhashi T, Yokohama A, Isa K, Ogasawara K, Uchikawa M.
-
Journal Title
Blood.
Volume: 119
Pages: 5301-10
Related Report
-
[Journal Article] Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity.2012
Author(s)
Kimura-Kataoka K, Yasuda T, Fujihara J, Toga T, Ono R, Otsuka Y, Ueki M, Iida R, Sano R, Nakajima T, Kominato Y, Kato H, Takeshita H.
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Journal Title
Electrophoresis.
Volume: 33
Pages: 2852-58
Related Report
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[Journal Article] A case of fatal drug intoxication showing a high-density duodenal content by postmortem computed tomography2011
Author(s)
Sano R, Takahashi K, Kominato Y, Araki T, Yamamoto K, Takei H, Otake H, Awata S, Akuzawa H, Tago Y, Aoki H
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Journal Title
Leg Med
Volume: 13
Pages: 39-40
Related Report
Peer Reviewed
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[Journal Article] Mutation of the GATA site in the erythroid cell-specific regulatory element of the ABO gene in a Bm subgroup individual
Author(s)
Nakajima T, Sano R, Takahashi Y, Kubo R, Takahashi K, Kominato Y, Tsukada J, Takeshita H, Yasuda T, Uchikawa M, Isa K, Ogasawara K.
-
Journal Title
Transfusion
Volume: (in press)
Related Report
Peer Reviewed
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