Role of oxytocin and oxytocin receptor in stress responses in the brain

• Project/Area Number: 23790735
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kochi University
• Principal Investigator: YAMAGUCHI Naoko 高知大学, 教育研究部医療学系, 助教 (50380324)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ストレス / オキシトシン / エストロゲン

Research Abstract

Oxytocin is one of the important factors to regulate stress responses in the brain. In this study, I examined the role of brain oxytocin system after restraint stress exposure using oxytocin receptor knockout female mice. The present results suggest that oxytocin receptor mediate acute restraint stress-induced expression of stress-related factors including corticotropin-releasing factor in the brain.

Research Products

• [Journal Article] Changes in oestrogen receptor-β mRNA expression in male rat brain with age (2012)
  • Author(s): Naoko Yamaguchi, Kazunari Yuri
  • Journal Title: J Neuroendocrinol Volume: 24 Issue: 2 Pages: 310-318
  • DOI: 10.1111/j.1365-2826.2011.02231.x
  • Peer Reviewed
• [Journal Article] Changes in oestrogen receptor-β mRNA expression in male rat brain with age. (2012)
  • Author(s): Yamaguchi N, Yuri K.
  • Journal Title: Journal of Neuroendocrinology Volume: 24 Pages: 310-318
  • Peer Reviewed
• [Journal Article] Early life stress disrupts peripubertal development of aggression in male mice. (2011)
  • Author(s): Tsuda MC, Yamaguchi N, Ogawa S.
  • Journal Title: Neuroreport Volume: 22 Pages: 259-263
  • Peer Reviewed
• [Presentation] Social experience during pubertal period influences development of socio-emotional behavior in male estrogen receptor β knockout mice (2012)
  • Author(s): Naoko Yamaguchi, Akiko Mizushiri, Shoko Sagoshi, Kazuyo Nagata, Mumeko C. Tsuda, Sonoko Ogawa
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市(名古屋国際会議場)
  • Year and Date: 2012-09-21
• [Presentation] マウスの養育行動におよぼすストレスの影響 (2012)
  • Author(s): 冨澤優美, 山口奈緒子, 永田知代, 佐越祥子, 津田夢芽子, 坂本敏郎, 小川園子
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 西宮市(関西学院大学)
  • Year and Date: 2012-05-12
• [Presentation] Age-related changes in estrogen receptor-β mRNA expression in male rat brain (2012)
  • Author(s): 山口奈緒子, 由利和也
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府市(山梨大学)
  • Year and Date: 2012-03-28
• [Presentation] Social experience during pubertal period influences development of socio-emotional behavior in male estrogen receptor β knockout mice. (2012)
  • Author(s): Yamaguchi N, Mizushiri A, Sagoshi S, Nagata K, Tsuda MC, Ogawa S.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市（ 名古屋国際会議場）
• [Presentation] マウスの養育行動におよぼすストレスの影響. (2012)
  • Author(s): 冨澤優美, 山口奈緒子, 永田知代, 佐越祥子, 津田夢芽子, 坂本敏郎, 小川園子.
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 西宮市（ 関西学院大学）
• [Presentation] Age-related changes in estrogen receptor-β mRNA expression in male rat brain. (2012)
  • Author(s): 山口奈緒子, 由利和也.
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府市（ 山梨大学）
• [Presentation] Disrupted development of peri-pubertal male aggression in maternally separated mice. (2011)
  • Author(s): Tsuda MC, Yamaguchi N, Ogawa S.
  • Organizer: 41th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC, USA（ Washington Convention Center）
• [Presentation] Hormonal and environmental regulation of social behavior. (2011)
  • Author(s): Ogawa S, Tsuda MC, Yamaguchi N, Sakamoto T, Kakeyama M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜市（ パシフィコ横浜）
• [Remarks] ホームページ
  • URL: http://www.kochi-ms.ac.jp/~ff_antm1/
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_antm1/