Alzheimer disease caused by vascular senescence and the mechanisms of prevention from it

• Project/Area Number: 23790737
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: OTA Hidetaka 東京大学, 医学部附属病院, 助教 (20431869)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 血管老化 / アルツハイマー型認知症 / Sirt1 / SIRT1 / 神経老化 / 血管内皮老化 / SAMP8マウス / 認知症 / 細胞老化 / テストステロン

Research Abstract

We found that treatment with testosterone ameliorated cognitive function and inhibited senescence of hippocampal vascular endothelial cells of SAMP8. Notably, SAMP8 showed enhancement of oxidative stress in the hippocampus. We observed that an NAD+-dependent deacetylase, SIRT1, played an important role in the protective effect of testosterone against oxidative stress-induced endothelial senescence.

Research Products

• [Journal Article] Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 miceprotective role of eNOS and SIRT1. (2012)
  • Author(s): Ota H, Akishita M, Akiyoshi T, Kahyo T,Setou M, Ogawa S, Iijima K, Eto M, Ouchi Y;
  • Journal Title: PLoS One. Volume: 7(1)
• [Journal Article] Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: (2012)
  • Author(s): Ota H
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: (2012)
  • Author(s): Ota H, Akishita M, Akiyoshi T, Kahyo T, Setou M, Ogawa S, Iijima K, Eto M, Ouchi Y.
  • Journal Title: PLoS One. Volume: 7
  • Peer Reviewed
• [Presentation] [シンポジウム]テストステロン医学の最先端 2012.テストステロンによるSAMP8 マウス認知能改善作用 (2012)
  • Author(s): 大田秀隆
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
• [Presentation] ライディッヒ細胞老化によるSAMP8 マウス認知機能障害に関する検討 (2012)
  • Author(s): 大田秀隆、秋下雅弘、小川純人、飯島勝矢、江頭正人、大内尉義
  • Organizer: 第54回日本老年医学会学術集会、
  • Place of Presentation: 東京