Brain cyclooxygenase-mediated mechanisms in stress response
| Project/Area Number |
23790745
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
TANAKA Kenjiro 高知大学, 教育研究部医療学系, 助教 (30552260)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | ストレス科学 / ストレス / 視床下部 / シクロオキシゲナーゼ / ニトロシル化 / プロスタノイド |
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| Research Abstract |
We demonstrated that pre-sympathetic neurons containing cyclooxygenase, a rate-limiting enzyme for the synthesis of prostanoids, in the hypothalamic paraventricular nucleus were involved in the activation of the sympatho-adrenomedullary outflow in rats. The present study also showed the possibility that the S-nitrosylation of brain cyclooxygenase is involved in the central activation of the sympatho-adrenomedullary outflow.
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Report
(3 results)
Research Products
(16 results)
