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Developing mechanisms of pseudoaldosteronism by taking licorice and its preventive method

Research Project

Project/Area Number 23790748
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNagoya City University

Principal Investigator

MAKINO Toshiaki  名古屋市立大学, 大学院・薬学研究科, 准教授 (80326561)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords漢方薬 / 副作用 / 偽アルドステロン症 / トランスポーター / 遺伝子多型
Research Abstract

One of the most incident adverse effects of kampo medicine is pseudoaldosteronism. This study revealed that 3-monoglucuronyl glycyrrhetinic acid (3MGA), which is one of the metabolites of glycyrrhizin, the main constituent of lycorice, is a substrate of organic anion transporters expressed in the membrane of renal epithelial cells, and can inhibit 11・-hydroxysteroid dehydrogenase, but that glycyrrhetinic acid, the main metabolite of glycyrrhizin can not. We can prevent to develop pseudoaldosteronism by monitoring the concentration of 3MGA in plasma or urine of the patients who take kampo medicine.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] 3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11β-hydroxysteroid dehydrogenase 22012

    • Author(s)
      Toshiaki Makino
    • Journal Title

      The Journal of Pharmacology and Experimental Therapeutics

      Volume: 342 Issue: 2 Pages: 297-304

    • DOI

      10.1124/jpet.111.190009

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 漢方薬の副作用~偽アルドステロン症のメカニズムとその発症予防策について2011

    • Author(s)
      牧野利明、大嶽信弘
    • Journal Title

      ファルマシア

      Volume: 47(5) Pages: 403-407

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 甘草の副作用、偽アルドステロン症発症推定原因物質 3MGA の ELISA による定量法の開発2013

    • Author(s)
      森永 紀、牧野利明、大北剛司、水上 元、正山征洋
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 漢方研究のターゲットとしてのトランスポーター2013

    • Author(s)
      牧野利明
    • Organizer
      日本薬物動態学会・トランスポーター研究会合同シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 甘草の副作用、偽アルドステロン症発症メカニズムに関する研究2011

    • Author(s)
      岡島恭子、 牧野利明、井上勝央、大嶽信弘、水上 元
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 甘草の副作用、偽アルドステロン症発症推定原因物質3MGAのELISAによる定量法の開発

    • Author(s)
      森永 紀
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Book] Mechanisms of licorice-induced pseudoaldosteronism, one of the most common side effects of traditional Japanese kampo medicine and traditional Chinese medicine2013

    • Author(s)
      Toshiaki Makino, Nobuhiro Ohtake
    • Publisher
      Nova Science Publishers
    • Related Report
      2012 Final Research Report
  • [Book] Mechanisms of licorice-induced pseudoaldosteronism, one of the most common side effects of traditional Japanese kampo medicine and traditional Chinese medicine“Traditional Medicine – New Research” ed. Yoshiharu Motoo2013

    • Author(s)
      Toshiaki Makino, Nobuhiro Ohtake
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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