Neuroprotective effects of a water-soluble extract from culture medium of Ganoderma lucidum mycelia against transient cerebral ischemia in streptozotocin-diabetic rats
| Project/Area Number |
23790750
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Josai University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 糖尿病 / 一過性脳虚血 / 酸化ストレス / 霊芝菌糸体培養培地抽出物（WER） / 抗酸化食品 / HMGB1 / HMGB-1 |
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| Research Abstract |
Diabetes mellitus is known to exacerbate cerebral ischemic injury. In the present study, we investigated anti-inflammatory effects of oral supplementation of a water-soluble extract from culture medium of Ganoderma lucidum mycelia (WER) on cerebral injury caused by middle cerebral artery occlusion and reperfusion (MCAO/Re) in rats with streptozotocin-induced diabetes. The diabetic state markedly aggravated MCAO/Re-induced cerebral damage, as assessed by infarct volume. Pretreatment with WER for two weeks significantly suppressed the exacerbation of damage in the brain of diabetic rats. WER also suppressed the production of superoxide radical, activation of HMGB1, and expression of proinflammatory cytokines in the ischemic penumbra.
These results suggest that daily intake of WER attenuates the exacerbation of cerebral ischemic injury in a diabetic state, which may be attributed to anti-apoptotic and anti-inflammatory effects via the improvement of augmented oxidative stress in the brain.
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Report
(4 results)
Research Products
(40 results)
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[Presentation] 霊芝菌糸体培養培地抽出物(MAK)中のシリンガ酸による神経保護効果の検討2014
Author(s)
玄美燕,岩田直洋,鈴木龍一郎,髙島諒平,神内伸也,鈴木史子,宮野義之,飯塚博,白瀧義明,岡﨑真理,日比野康英
Organizer
日本薬学会第134年会
Place of Presentation
熊本大学
Year and Date
2014-03-28
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