| Project/Area Number |
23790754
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Keio University (2012)
Aichi Gakuin University (2011) |
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Principal Investigator |
KOTANI Hitoshi 慶應義塾大学, 医学部, 特任助教 (10594640)
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| Research Collaborator |
INOUE Makoto 愛知学院大学, 薬学部, 教授 (50191888)
NAGATSU Akito 金城学院大学, 薬学部, 教授 (70244572)
MAKISHIMA Makoto 日本大学, 医学部, 教授 (70346146)
TANABE Hiroki 愛知学院大学, 薬学部, 講師 (10415606)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 東洋医学 / 核内受容体 / 生薬学 / 天然物化学 / メタボリックシンドローム / 動脈硬化 / レチノイド / RXR / 漢方方剤 / honokiol / LXR / 天然物 / 厚朴 |
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| Research Abstract |
Honokiol was found to be a novel natural RXR ligand and show some synergistic effects in combination with other nucler receptor agonists. As one of pharmacological actions, honokiol appears to have beneficial effect on atherogenesis or metabolic syndrome.
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