| Project/Area Number |
23790756
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 慢性ストレス / SARTストレス / 視床下部 / 自律神経 / CRF作動性神経 / 低血圧 / 脳内神経活動 / CRF / 急性ストレス / c-Fos / 神経活性 |
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| Research Abstract |
I examined functional changes of the central nervous system (CNS) using SART-stressed mice in the formation process of chronic stress related to the onset of illness.
Chronic stress reduced the neural activity of the hypothalamic paraventricular nucleus (PVN), the dorsomedial hypothalamic nucleus (DMH) and the Pallidal raphe nucleus (RPa) gradually. It was observed that chronic stress decreased the neural activity of the CRF neuron in PVN. These abnormalities were improved by the anti-anxiety drug diazepam.
In SART-stressed mice, it was suggested that the chronic stress-induced abnormality of the neural activity of PVN, DMH and RPa, which is involved in the autonomic nervous system and endocrine system, is broken homeostasis. It was thought that the SART stress-induced decrease of neural activity in DMH is related to blood pressure regulation and could be one factor in hypotension onset.
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