The plasma L-Cystine / L-Glutamate imbalance in cirrhosis influences the function of antigen-presenting cell.
| Project/Area Number |
23790762
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
KAKAZU Eiji 東北大学, 東北メディカル・メガバンク機構, 助教 (20509377)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血漿アミノ酸不均衡 / 非代償性肝硬変 / 単球 / 腎機能障害 / L-シスチン / アミノ酸 / 肝硬変 / 免疫 / L-グルタミン酸 / アミノ酸不均衡 |
|---|
| Research Abstract |
We demonstrated for the first time that an L-Cys/L-Glu imbalance, especially high levels of L-Cys, increases pro-inflammatory cytokines, especially TNF-alpha from peripheral CD14+ monocytes under the amino acid condition of advanced cirrhosis in vitro, and these results are consistent with the relationships among plasma L-Cys and TNF-alpha in patients with advanced cirrhosis. This study may provide a new approach for future studies to ameliorate the immune dysfunction in patients with advanced cirrhosis.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012
Author(s)
Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
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Journal Title
Journal of clinical microbiology
Volume: 50
Issue: 3
Pages: 857-866
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012
Author(s)
Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
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Journal Title
Virology
Volume: 22(2)
Issue: 2
Pages: 377-85
DOI
Related Report
Peer Reviewed
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[Journal Article] The Nutritional Index 'CONUT' Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases2011
Author(s)
Fukushima, K., Ueno, Y., Kawagishi, N., Kondo, Y., Inoue, J., Kakazu, E., Ninomiya, M., Wakui, Y., Saito, N., Satomi, S., and Shimosegawa, T.
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 224
Issue: 3
Pages: 215-219
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Journal Article] Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients2011
Author(s)
Inoue, J., Ueno, Y., Wakui, Y., Fukushima, K., Kondo, Y., Kakazu, E., Ninomiya, M., Niitsuma, H., and Shimosegawa, T.
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Journal Title
The Journal of infectious diseases
Volume: 204
Issue: 7
Pages: 1017-1025
DOI
Related Report
Peer Reviewed
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