Cross talk between the innate immune response and trans- differentiation/carcinogenesis in the gastric epithelium

Research Project

Project/Area Number	23790766
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Tohoku University
Principal Investigator	ASANO Naoki 東北大学, 病院, 助教 (20526454)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	上部消化管学(食道、胃、十二指腸) / Cdx2 / NOD1 / 腸上皮化生
Research Abstract	Helicobacter pylori (H. pylori) infection induced Cdx2 expression via the activation of NF-κB in gastric epithelial cells. On the other hand, knocking down NOD1 enhanced this induction whereas pre-stimulation with NOD1 ligand and over-expression of TRAF3 had a suppressive role on this induction. In vivo studies with H. pylori infected mice revealed that the absence of NOD1 leads to enhanced formation of intestinal metaplasia and induction of Cdx2.

Report

(3 results)