Analysis of relation between entero colitis with enteric neuron

• Project/Area Number: 23790769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Chiba University
• Principal Investigator: FUJIMURA Lisa 千葉大学, バイオメディカル研究センター, 助教 (30376363)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 下部消化管学(小腸、大腸) / 炎症性腸疾患 / 腸管神経 / 一酸化窒素 / Ncx-KOマウス / 腸内フローラ / 腸管バリア / 腸管免疫 / Ncx-KO

Research Abstract

Using the hyper innervated Ncx-KO mice, the nitric oxide from enteric neuron controls the expression of e-cadherin of enteric endothelial cells and intestinal permeability and has an important roles in maintain the homeostasis of intestinal flora. This study indicated that the enteric neuron has roles in maintenance of enteric homeostasis and in enteric colitis.

Research Products

• [Journal Article] Integration of the mouse sperm fertilization-related protein equatorin into the acrosome during spermatogenesis as revealed by super-resolution and immunoelectron microscopy (2013)
  • Author(s): Ito C, Yamatoya K, Yoshida K, Fujimura L, Hatano M, Miyado K, Toshimori K.
  • Journal Title: Cell Tissue Res
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23564009
  • Peer Reviewed
• [Journal Article] Integration of the mouse sperm fertilization-related protein equatorin into the acrosome during spermatogenesis as revealed by super-resolution and immunoelectron microscopy (2013)
  • Author(s): Ito C, Yamatoya K, Yoshida K, Fujimura L, Hatano M, Miyado K, Toshimori K
  • Journal Title: Cell Tissue Res Volume: 352(3) Issue: 3 Pages: 739-750
  • DOI: 10.1007/s00441-013-1605-y
  • Peer Reviewed
• [Journal Article] Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma (2012)
  • Author(s): Kinoshita T, Nohata N, Watanabe-Takano H, Yoshino H, Hidaka H, Fujimura L, Fuse M, Yamasaki T, Enokida H, Nakagawa M, Hanazawa T, Okamoto Y, Seki N.
  • Journal Title: Int. J. Oncol Volume: (印刷中) Pages: 1770-8
  • DOI: 10.3892/ijo.2012.1390
  • Peer Reviewed
• [Journal Article] Tumor suppressive microRNA-133a regulates novel targets : moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma (2012)
  • Author(s): Takashi Kinoshita
  • Journal Title: Biochemical and biophysical research communications Volume: 418 Issue: 2 Pages: 378-83
  • DOI: 10.1016/j.bbrc.2012.01.030
  • Peer Reviewed
• [Journal Article] Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells (2012)
  • Author(s): Fujimura L, Hatano M.
  • Journal Title: Methods Mol Biol Volume: 839 Pages: 173-85
  • DOI: 10.1007/978-1-61779-510-7_14
  • ISBN: 9781617795091, 9781617795107
  • Peer Reviewed
• [Journal Article] Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma (2012)
  • Author(s): Kinoshita T, Nohata N, Yoshino H, Hanazawa T, Kikkawa N, Fujimura L, Chiyomaru T, Kawakami K, Enokida H, Nakagawa M, Okamoto Y, Seki N.
  • Journal Title: Int J Oncol Volume: 40 Pages: 185-93
  • DOI: 10.3892/ijo.2011.1196
  • Peer Reviewed
• [Journal Article] Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma. (2012)
  • Author(s): Kinoshita T, Nohata N, Fuse M, Hanazawa T, Kikkawa N, Fujimura L, Watanabe-Takano H, Yamada Y, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
  • Journal Title: Biochem Biophys Res Commun. Volume: 418(2) Pages: 378-83
  • Peer Reviewed
• [Journal Article] Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells. (2012)
  • Author(s): Fujimura L, Hatano M.
  • Journal Title: Methods Mol Biol. Volume: 839 Pages: 173-85
  • Peer Reviewed
• [Journal Article] Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC) (2011)
  • Author(s): Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L, Kawakami K, Chiyomaru T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
  • Journal Title: J Hum Genet Volume: 56(8) Issue: 8 Pages: 595-601
  • DOI: 10.1038/jhg.2011.66
  • Peer Reviewed
• [Journal Article] Glutathione S-transferase P1 (GSTP1) suppresses cell apoptosis and its regulation by miR-133α in head and neck squamous cell carcinoma (HNSCC). (2011)
  • Author(s): Mutallip M, Nohata N, Hanazawa T, Kikkawa N, Horiguchi S, Fujimura L, Kawakami K, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
  • Journal Title: Int J Mol Med. 2011 Mar;27(3):345-52 Volume: 27(3) Pages: 345-52
  • Peer Reviewed
• [Presentation] Nczf disruption results in earlyembryonic lethality by deregulating p27 expression (2012)
  • Author(s): Teratake Y, Hasegawa Y, Fujimura L, Takano H, Tokuhisa T, Hatano M
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] Nitric oxide derived from enteric neurons regulates intestinal barrier function (2012)
  • Author(s): Fujimura L, Sakamoto A, Arima M, Tokuhisa T, Hatano M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] Role of IL-33 in a suppressive function of Bcl6 for IL-4 production by memory Th2 cells (2012)
  • Author(s): Arima M, Taniguchi T, Fujimura L, Sakamoto A, Hatano M, Tokuhisa T
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Phf11 promotes IgE class switch recombination in activated B cells (2012)
  • Author(s): Yamamoto T, Tanigichi T, Inamine A, Fujimura L, Sakamoto A, Hatano M, Tokuhisa T, Arima M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Nitric oxide derived from enteric neurons regulates intestinal barrier function (2012)
  • Author(s): Fujimura L
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Phf11 promotes IgE class switch recombination in activated B cells. (2012)
  • Author(s): Yamamoto T
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Role of IL-33 in a suppressive function of Bcl6 for IL-4 production by memory Th2 cells (2012)
  • Author(s): Arima M
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Nczf disruption results in early embryonic lethality by disregulating p27 expression (2011)
  • Author(s): 寺竹洋一、長谷川勇太、藤村理 紗 、高野晴子、徳久剛史、幡野雅彦
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] 樹状細胞によるTh2誘導サイトカイン産生に対するBcl6の抑制作用 (2011)
  • Author(s): Kohashi Y,Inamine A,Inage S,Takano H,Fujimura L,Sakaoto A,Hatano M,Tokuhisa T,Arima M
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] Ncx欠損は腸管上皮バリアの異常により腸炎を発症する (2011)
  • Author(s): 藤村理紗、坂本明美、有馬雅史、徳久剛史、幡野雅彦
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 好塩基球のTh2サイトカイン遺伝子発現制御におけるGATA2の役割 (2011)
  • Author(s): Hanazumi N,Inamine A,Kohashi Y,Takano H,Fujimura L,Sakaoto A,Hatano M,Tokuhisa T,Arima M
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] Ncx欠損は腸管上皮バリアの異常により腸炎を発症する (2011)
  • Author(s): 藤村理紗、坂本明美、有馬雅史、徳久剛史、幡野雅彦
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 千葉
• [Presentation] Nczf disuruption results in early embrionic lethality by disregulating p27 expression (2011)
  • Author(s): 寺竹洋一、長谷川勇太、藤村理紗、高野晴子、徳久剛史、幡野雅彦
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Nczf disruption results in early embryonic lethality by deregulating p27 expression
  • Author(s): Teratake Y
  • Organizer: 日本分子生物学会
  • Place of Presentation: 福岡