| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In the present study, immunohistochemical analysis demonstrated that stepwise increase in LI-cadherin expression and incidence of gastrointestinal phenotype (one of mucin phenotypes) was observed with increasing the grade of biliary intraepithelial neoplasia (BilIN) (p<0.001). Logistic regression analysis revealed that the high grade BilIN (BilIN-2/3) was the only independently significant factor associated with LI-cadherin expression (odds ratio 25.9, p=0.002). The serum level of LI-cadherin was detected in 3 patients from patients with 14 intrahepatic cholangiocarcinoma (ICC). These 3 patients were TNM stage III in 1 case and TNM stage IVB in 2 cases. The results in this study suggest that the expression of LI-cadherin and gastrointestinal phenotype in high grade BilIN may be a serious lesion in the multistep process of ICC carcinogenesis, while the serum detection of LI-cadherin in ICC may be a marker for predicting late-stage disease.
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