Identification of molecules regulating the plasticity of interstitial cells of Cajal (ICC) in the experimental colitis and investigation of stem cells of ICC
| Project/Area Number |
23790782
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Satomi 福井大学, 医学部, 特命助教 (00595283)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | カハール介在細胞(ICC) / 腸炎 / トリニトロベンゼンスルホン酸 / マイクロアレイ / カハール介在細胞 / 発現解析 / カハール介在細胞（ICC） / 消化管運動 / c-KIT |
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| Research Abstract |
In this study, we examined the gene expression of interstitial cells of Cajal, which are thought to be the regulatory cells of gut motility, in trinitrobenzene sulfonic acid-induced experimental colitis of mice. By DNA microarray we found some candidate genes related to ICC recovery including cell growth factorsand transcription factors. These results may lead to the development of new therapeutic strategy for motility disorder of gut
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Report
(3 results)
Research Products
(14 results)
