| Project/Area Number |
23790783
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KASAI Hirotake 山梨大学, 医学工学総合研究部, 助教 (20324189)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | HCV / 肝がん / ヒストン修飾 / 肝炎 / 肝細胞癌 / 感染症 / C型肝炎 / ウイルス / 発癌 / ヒストンの分子修飾 |
|---|
| Research Abstract |
Infection with hepatitis C virus (HCV) affects 3% of the human population, or roughly 170 million individuals worldwide, and it leads to severe liver disorders,such as liver cancer, hepatocellular carcinoma (HCC). Recently, high efficient drugs against HCV have been developed. However, the risk of carcinogenesis is still high after the virus exclusion. It is important to understand what is taking place early in carcinogenesis by the HCV infection. In this study, I focused on the effect of HCV-Core protein on regulation of gene expression. The Core protein was known as important protein for HCV-oncogenesis. As a result, it followed that it was expected that the expression of Core protein went to the carcinogenesis by rearranging modification of the histone protein which coordinated gene expression.
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