Dissecting themechanism of plasmacytoid dendritic cell activation triggered by hepatitis C virus-infected cells
| Project/Area Number |
23790790
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Ken 京都大学, 医学研究科, 助教 (60594372)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ウイルス / 感染症 / 免疫学 / 肝臓病学 / 免疫 |
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| Research Abstract |
Plasmacytoid dendritic cells (pDCs) sense hepatitis C virus (HCV)-infected cells and produce interferon (IFN) in a cell-contact-dependent manner. The aim of this study was to dissect the molecular mechanism underlying this event. In contrast to conventional pDC signaling, the results show that HCV-infected cells do not activate NF・B despite the robust IFN response, suggesting the unsuspected signaling mechanism unique to the virus-infected cell-triggered pDC activation. The mechanism of HCV RNA transfer from infected cells to pDC remains to be elucidated.
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Report
(3 results)
Research Products
(4 results)
