Dissecting themechanism of plasmacytoid dendritic cell activation triggered by hepatitis C virus-infected cells

Research Project

Project/Area Number	23790790
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Kyoto University
Principal Investigator	TAKAHASHI Ken 京都大学, 医学研究科, 助教 (60594372)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	ウイルス / 感染症 / 免疫学 / 肝臓病学 / 免疫
Research Abstract	Plasmacytoid dendritic cells (pDCs) sense hepatitis C virus (HCV)-infected cells and produce interferon (IFN) in a cell-contact-dependent manner. The aim of this study was to dissect the molecular mechanism underlying this event. In contrast to conventional pDC signaling, the results show that HCV-infected cells do not activate NF・B despite the robust IFN response, suggesting the unsuspected signaling mechanism unique to the virus-infected cell-triggered pDC activation. The mechanism of HCV RNA transfer from infected cells to pDC remains to be elucidated.

Report

(3 results)