| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Helicobacter pylori dupA can be divided into two types according to the presence or absence of the mutation. In addition, dupA has two types with different lengths depend on the presence of approximately 600 bp in the putative 5' region (presence; long-type and absence; short-type). dupA was predicted to form a type IV secretary system (T4SS) with vir genes around dupA (dupA cluster). We reported that intact long-type dupA is a real virulence marker for severe outcomes. In addition, the presence of a complete dupAcluster (dupA and all adjacent vir genes) was associated with duodenal ulcer development.
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