Novel type IV secretion system of Helicobacter pylori
| Project/Area Number |
23790798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Oita University |
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Principal Investigator |
SHIOTA Seiji 大分大学, 医学部, 助教 (00420646)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ヘリコバクター・ピロリ / dupA / Helicobacter pylori |
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| Research Abstract |
Helicobacter pylori dupA can be divided into two types according to the presence or absence of the mutation. In addition, dupA has two types with different lengths depend on the presence of approximately 600 bp in the putative 5' region (presence; long-type and absence; short-type). dupA was predicted to form a type IV secretary system (T4SS) with vir genes around dupA (dupA cluster). We reported that intact long-type dupA is a real virulence marker for severe outcomes. In addition, the presence of a complete dupAcluster (dupA and all adjacent vir genes) was associated with duodenal ulcer development.
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Report
(3 results)
Research Products
(37 results)
