Analysis of vanin-1 in non-alcoholic fatty liver disease
| Project/Area Number |
23790799
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂肪肝 / 脂肪滴 / 脂質代謝 / 脂質 / 内科 / 栄養学 |
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| Research Abstract |
We analyzed the expression of hepatic vanin-1 mRNA following the administration of a high-fat diet in mice as well as free fattyacids in hepatocyte cultures and speculated its possible mechanism. Vanin-1 mRNA levels in the livers of mice were upregulated within a day of the high-fat diet. An in vitroanalysis using HuH-7 cells revealed a significant upregulation of vanin-1 mRNA by low oleic acid concentration; however, lipid accumulation in hepatocytes was not affected at this concentration. As a result of examining with various free fatty acids, it was shown that vanin-1 mRNA was upregulated by the oleic acid and the linoleic acid that makes the lipid droplet easily in the hepatocyte.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes2013
Author(s)
Takahashi, N. , Yoshizaki, T., Hiranaka, N., Suzuki, T., Yui, T., Akanuma, M., Kanazawa, K., Yoshida, M., Naito, S., Fujiya, M., Kohgo, Y. and Ieko. M
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Journal Title
Biochem. Biophys. Res. Comm
Volume: 431
Issue: 1
Pages: 25-30
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes2011
Author(s)
Takahashi, N., Yoshizaki, T., Hiranaka, N., Suzuki, T., Yui, T., Akanuma, M., Oka, K., Kanazawa, K., Yoshida, M., Naito, S., Fujiya, M., Kohgo, Y. and Ieko, M
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Journal Title
Biochem. Biophys. Res. Comm
Volume: 415
Issue: 1
Pages: 200-205
DOI
NAID
Related Report
Peer Reviewed
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