Research Project
Grant-in-Aid for Young Scientists (B)
We analyzed the expression of hepatic vanin-1 mRNA following the administration of a high-fat diet in mice as well as free fattyacids in hepatocyte cultures and speculated its possible mechanism. Vanin-1 mRNA levels in the livers of mice were upregulated within a day of the high-fat diet. An in vitroanalysis using HuH-7 cells revealed a significant upregulation of vanin-1 mRNA by low oleic acid concentration; however, lipid accumulation in hepatocytes was not affected at this concentration. As a result of examining with various free fatty acids, it was shown that vanin-1 mRNA was upregulated by the oleic acid and the linoleic acid that makes the lipid droplet easily in the hepatocyte.
All 2013 2012 2011 Other
All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (12 results)
Biochem. Biophys. Res. Comm
Volume: 431 Issue: 1 Pages: 25-30
10.1016/j.bbrc.2012.12.112
120006522750
Journal of Clinical Biochemistry and Nutrition
Volume: 51 Issue: 3 Pages: 163-169
10.3164/jcbn.12-06
130004466691
Volume: 415 Issue: 1 Pages: 200-205
10.1016/j.bbrc.2011.10.060
120004461828